Targeting the r-spine: Design, synthesis, and biological evaluation of novel type I1/2 p38α MAP kinase inhibitors with excellent selectivity, high potency, and prolonged target residence time. Implication for cancer- and CNS-applications

被引:0
作者
Laufer, Stefan [1 ]
Wentsch, Heike [1 ]
Walter, Niklas [1 ]
Laemmerhofer, Michael [1 ]
Buijsman, Roger [2 ]
Rauh, Daniel [3 ]
Zender, Lars [4 ]
机构
[1] Univ Tubingen, Dept Pharm & Biochem, Tubingen, Germany
[2] Netherlands Translat Res Ctr, NL-5342 Oss, Netherlands
[3] Tech Univ Dortmund, Chem Biol, Dortmund, Germany
[4] Univ Hosp Tubingen, Dept Internal Med 8, D-72076 Tubingen, Germany
来源
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2019年 / 258卷
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中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
151-COMP
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页数:2
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