Interactions between glial cells and the blood-brain barrier and their role in Alzheimer's disease

被引：59

作者：

Zhao, Ming ^{[1
,2
]}

Jiang, Xue-Fan ^{[1
,2
]}

Zhang, Hui-Qin ^{[1
]}

Sun, Jia-Hui ^{[1
,2
]}

Pei, Hui ^{[1
]}

Ma, Li-Na ^{[1
]}

Cao, Yu ^{[1
]}

Li, Hao ^{[1
]}

机构：

[1] China Acad Chinese Med Sci, Xiyuan Hosp, Inst Geriatr, Beijing 100091, Peoples R China

[2] Beijing Univ Chinese Med, Beijing 100029, Peoples R China

来源：

AGEING RESEARCH REVIEWS | 2021年 / 72卷

基金：

中国国家自然科学基金;

关键词：

Alzheimer's disease; Blood-brain barrier; Astrocytes; Microglia; Oligodendrocytes; VASCULAR BASEMENT-MEMBRANE; AMYLOID-BETA-PEPTIDE; ARCSWE MOUSE MODEL; NEUROVASCULAR UNIT; TRANSFORMING GROWTH-FACTOR-BETA-1; CEREBRAL MICROBLEEDS; EXTRACELLULAR-MATRIX; ACTIVATED MICROGLIA; FUNCTIONAL RECOVERY; TIGHT JUNCTIONS;

D O I：

10.1016/j.arr.2021.101483

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Alzheimer's disease (AD), which is an irreversible neurodegenerative disorder characterized by senile plaques and neurofibrillary tangles, is the most common form of dementia worldwide. However, currently, there are no satisfying curative therapies for AD. The blood-brain barrier (BBB) acts as a selective physical barrier and plays protective roles in maintaining brain homeostasis. BBB dysfunction as an upstream or downstream event promotes the onset and progression of AD. Moreover, the pathogenesis of AD caused by BBB injury hasn't been well elucidated. Glial cells, BBB compartments and neurons form a minimal functional unit called the neurovascular unit (NVU). Emerging evidence suggests that glial cells are regulators in maintaining the BBB integrity and neuronal function. Illustrating the regulatory mechanism of glial cells in the BBB assists us in drawing a glialvascular coupling diagram of AD, which may offer new insight into the pathogenesis of AD and early intervention strategies for AD. This review aims to summarize our current knowledge of glial-BBB interactions and their pathological implications in AD and to provide new therapeutic potentials for future investigations.

引用

页数：13

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