Microwave-Assisted One-Pot Three Component Synthesis of Some Thiazolyl(Hydrazonoethyl)Thiazoles as Potential Anti-Breast Cancer Agents

被引：15
作者：
Mahmoud, Huda K. [1 ]
Abdelhady, Hyam A. [1 ]
Elaasser, Mahmoud M. [2 ]
Hassain, Doaa Z. H. [1 ]
Gomha, Sobhi M. [1 ,3 ]
机构：
[1] Cairo Univ, Fac Sci, Dept Chem, Giza, Egypt
[2] Al Azhar Univ, Reg Ctr Mycol & Biotechnol, Cairo, Egypt
[3] Islamic Univ Madinah, Fac Sci, Chem Dept, Al Madinah, Al Munawwarah, Saudi Arabia
来源：
POLYCYCLIC AROMATIC COMPOUNDS | 2022年 / 42卷 / 10期
关键词：
Microwave irradiation; hydrazones; hydrazonoyl halides; cyclization; multi-component reactions; MCF-7; BIOLOGICAL EVALUATION; MULTICOMPONENT REACTIONS; CYTOTOXICITY EVALUATION; THIAZOLE DERIVATIVES; ANTITUMOR; ANALOGS; MOIETY;
D O I：
10.1080/10406638.2021.1998146
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
In the present work, 1-(4-methyl-2-(2-(1-(thiophen-2-yl)ethylidene)hydrazinyl) thiazol-5-yl)ethanone was used as building block for synthesis of novel four series of 5-(1-(2-(thiazol-2-yl)hydrazono)ethyl) thiazole derivatives in a one-pot three-component reaction using both thermal heating and microwave irradiation for comparison. All the structures of the synthesized compounds were elucidated based on their elemental analyses and spectral measurements. The bioactivities of the synthesized compounds were evaluated their antitumor activities against MCF-7 tumor cells in comparison with vinblastine sulfate and cisplatin reference drugs using MTT assay and the results revealed promising activities of five compounds (4d, 8b, 12e, 4a, and 12d).
引用
收藏
页码：7232 / 7246
页数：15
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