Oncolytic Poxviruses

被引：77
作者：
Chan, Winnie M. [1 ]
McFadden, Grant [1 ]
机构：
[1] Univ Florida, Coll Med, Dept Mol Genet & Microbiol, Gainesville, FL 32610 USA
来源：
ANNUAL REVIEW OF VIROLOGY, VOL 1 | 2014年 / 1卷
关键词：
vaccinia virus; myxoma virus; virus tropism; oncolytic; virotherapeutics; virotherapy; ENVELOPED VACCINIA VIRUS; CANCER-RELATED ANEMIA; MYXOMA-VIRUS; CLINICAL-TRIAL; TUMOR-GROWTH; HUMAN-ERYTHROPOIETIN; APOPTOTIC MIMICRY; THYMIDINE KINASE; IMMUNE-RESPONSES; CELL CARRIERS;
D O I：
10.1146/annurev-virology-031413-085442
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Current standard treatments of cancer can prolong survival of many cancer patients but usually do not effectively cure the disease. Oncolytic virotherapy is an emerging therapeutic for the treatment of cancer that exploits replication-competent viruses to selectively infect and destroy cancerous cells while sparing normal cells and tissues. Clinical and/or preclinical studies on oncolytic viruses have revealed that the candidate viruses being tested in trials are remarkably safe and offer potential for treating many classes of currently incurable cancers. Among these candidates are vaccinia and myxoma viruses, which belong to the family Poxviridae and possess promising oncolytic features. This article describes poxviruses that are being developed for oncolytic virotherapy and summarizes the outcomes of both clinical and preclinical studies. Additionally, studies demonstrating superior efficacy when poxvirus oncolytic virotherapy is combined with conventional therapies are described.
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收藏
页码：191 / 214
页数：24
相关论文
共 147 条
[1]   Preferential Replication of Systemically Delivered Oncolytic Vaccinia Virus in Focally Irradiated Glioma Xenografts [J].
Advani, Sunil J. ;
Buckel, Lisa ;
Chen, Nanhai G. ;
Scanderbeg, Daniel J. ;
Geissinger, Ulrike ;
Zhang, Qian ;
Yu, Yong A. ;
Aguilar, Richard J. ;
Mundt, Arno J. ;
Szalay, Aladar A. .
CLINICAL CANCER RESEARCH, 2012, 18 (09) :2579-2590
[2]  
ANDREWES CH, 1955, BRIT J EXP PATHOL, V36, P18
[3]   ANTIGENIC DIFFERENCE BETWEEN INTRACELLULAR AND EXTRACELLULAR RABBITPOX VIRUS [J].
APPLEYARD, G ;
HAPEL, AJ ;
BOULTER, EA .
JOURNAL OF GENERAL VIROLOGY, 1971, 13 (OCT) :9-+
[4]   Identification of host range mutants of myxoma virus with altered oncolytic potential in human glioma cells [J].
Barrett, John W. ;
Alston, Lindsay R. ;
Wang, Fuan ;
Stanford, Marianne M. ;
Gilbert, Philippe-Alexandre ;
Gao, Xiujuan ;
Jimenez, June ;
Villeneuve, Danielle ;
Forsyth, Peter ;
McFadden, Grant .
JOURNAL OF NEUROVIROLOGY, 2007, 13 (06) :549-560
[5]   M135R is a novel cell surface virulence factor of myxoma virus [J].
Barrett, John W. ;
Sypula, Joanna ;
Wang, Fuan ;
Alston, Lindsay R. ;
Shao, Zhuhong ;
Gao, Xiujuan ;
Irvine, Timothy S. ;
McFadden, Grant .
JOURNAL OF VIROLOGY, 2007, 81 (01) :106-114
[6]   Immunomodulatory proteins of myxoma virus [J].
Barrett, JW ;
Cao, JX ;
Hota-Mitchell, S ;
McFadden, G .
SEMINARS IN IMMUNOLOGY, 2001, 13 (01) :73-84
[7]   Selective Purging of Human Multiple Myeloma Cells from Autologous Stem Cell Transplantation Grafts using Oncolytic Myxoma Virus [J].
Bartee, Eric ;
Chan, Winnie M. ;
Moreb, Jan S. ;
Cogle, Christopher R. ;
McFadden, Grant .
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2012, 18 (10) :1540-1551
[8]   Virotherapy Using Myxoma Virus Prevents Lethal Graft-versus-Host Disease following Xeno-Transplantation with Primary Human Hematopoietic Stem Cells [J].
Bartee, Eric ;
Meacham, Amy ;
Wise, Elizabeth ;
Cogle, Christopher R. ;
McFadden, Grant .
PLOS ONE, 2012, 7 (08)
[9]   Human cancer cells have specifically lost the ability to induce the synergistic state caused by tumor necrosis factor plus interferon-β [J].
Bartee, Eric ;
McFadden, Grant .
CYTOKINE, 2009, 47 (03) :199-205
[10]   The Addition of Tumor Necrosis Factor plus Beta Interferon Induces a Novel Synergistic Antiviral State against Poxviruses in Primary Human Fibroblasts [J].
Bartee, Eric ;
Mohamed, Mohamed R. ;
Lopez, M. Cecilia ;
Baker, Henry V. ;
McFadden, Grant .
JOURNAL OF VIROLOGY, 2009, 83 (02) :498-511
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