The potential role of ATF3 on immune response is regulated by BMP10 through Smad dependent pathway

被引：5
作者：
Wang, Yong [1 ,4 ]
Zhang, Yi-Wei [2 ,3 ]
Xu, Li [5 ]
Xin, Hong-bo [1 ]
机构：
[1] Sichuan Univ, Natl Key Lab Biotherapy, Lab Cardiovasc Dis, W China Hosp, Chengdu 610041, Peoples R China
[2] Indiana Univ Sch Med, Dept Biochem & Mol Biol, Indianapolis, IN 46202 USA
[3] Simon Canc Ctr, Indianapolis, IN 46202 USA
[4] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing Key Lab Neurol, Chongqing 400016, Peoples R China
[5] Chongqing Med Univ, Affiliated Hosp 1, Dept Resp Med, Chongqing 400016, Peoples R China
来源：
MEDICAL HYPOTHESES | 2011年 / 76卷 / 05期
关键词：
ACTIVATING TRANSCRIPTION FACTOR-3; SIGNALING PATHWAYS; INDUCED APOPTOSIS; IFN-GAMMA; EXPRESSION; PROTECTS; SUPPRESSES; INDUCTION; BINDING; CELLS;
D O I：
10.1016/j.mehy.2011.01.033
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
It is hypothesis that ATF3 is a downstream component of BMP10. The possible function of ATF3 on immune response is partially regulated by BMP10 via Smad dependent pathway. BMP10 is highly expressed in blood cells during embryonic development based on our in situ hybridization. The expression of ATF3 is enhanced by BMP10 in overexpression transgenic mice. Both BMP10 and ATF3 can response to stress stimulate, and ATF3 is well understood as a stress inducible gene which possible contributes to immune response. The Smad dependent pathway is well established for BMP10 in regulation expression of downstream targets. It would be interesting for us to determine the relationship between BMP10 and ATF3, especially to understand the mechanism of BMP10 and ATF3 effecting on heart development, as well as immune response exposed to stress stimulates. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：685 / 688
页数：4
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