Encapsulation and controlled release of L-leuprolide from poly(β-hydroxyalkanoate)s: impact of microstructure and chemical functionalities

被引：17

作者：

Ajellal, Noureddine ^{[1
]}

Thomas, Christophe M. ^{[1
]}

Aubry, Thierry ^{[2
]}

Grohens, Yves ^{[3
]}

Carpentier, Jean-Francois ^{[1
]}

机构：

[1] Univ Rennes 1, CNRS, UMR Sci Chim 6226, F-35042 Rennes, France

[2] Univ Bretagne Occidentale, Equipe Rheol, Lab Ingn Mat Bretagne, F-29238 Brest 3, France

[3] Univ Bretagne Sud, Equipe E2PIC, Lab Ingn Mat Bretagne, F-56321 Lorient, France

来源：

NEW JOURNAL OF CHEMISTRY | 2011年 / 35卷 / 04期

关键词：

MOLECULAR-WEIGHT POLY(L-LACTIDE); RING-OPENING POLYMERIZATION; PHOSPHATE-BUFFERED SOLUTION; BETA-BUTYROLACTONE; IN-VITRO; ENZYMATIC DEGRADATION; ACID) MICROSPHERES; PLGA MICROSPHERES; POLY(LACTIC ACID); DRUG-RELEASE;

D O I：

10.1039/c0nj00998a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A systematic study on the encapsulation and drug release efficiency of L-leuprolide acetate (LeA) with a series of different functionalized poly(beta-hydroxyalkanoate)s (PHAs) is reported. Significant differences on the in vitro release kinetics of LeA, depending essentially on the microstructure, chemical functionality, and molecular weights of polymers, have been evidenced. Better controlled released kinetics were observed with highly isotactic poly(beta-hydroxybutyrate) (i-PHB) and syndiotactic dihydroxylated-PHA.

引用

页码：876 / 880

页数：5

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