The neonatal brain in critical congenital heart disease: Insights and future directions

被引：105

作者：

Peyvandi, Shabnam ^{[1
]}

Latal, Beatrice ^{[2
,3
]}

Miller, Steven P. ^{[4
]}

McQuillen, Patrick S. ^{[5
]}

机构：

[1] Univ Calif San Francisco, Div Pediat Cardiol, Benioff Childrens Hosp, San Francisco, CA 94143 USA

[2] Univ Childrens Hosp Zurich, Child Dev Ctr, Zurich, Switzerland

[3] Childrens Res Ctr, Zurich, Switzerland

[4] Univ Toronto, Hosp Sick Children, Dept Neurol, Toronto, ON, Canada

[5] Univ Calif San Francisco, Div Crit Care, Benioff Childrens Hosp, San Francisco, CA 94143 USA

来源：

NEUROIMAGE | 2019年 / 185卷

关键词：

Congenital heart disease; Brain injury; Brain development; Neurodevelopment; HYPOTHERMIC CIRCULATORY ARREST; WHITE-MATTER; NEURODEVELOPMENTAL OUTCOMES; CARDIOPULMONARY BYPASS; CARDIAC-SURGERY; QUANTITATIVE ASSESSMENT; D-TRANSPOSITION; GREAT-ARTERIES; INJURY; ADOLESCENTS;

D O I：

10.1016/j.neuroimage.2018.05.045

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neurodevelopmental outcomes are impaired in survivors of critical congenital heart disease (CHD) in several developmental domains including motor, cognitive and sensory outcomes. These deficits can extend into the adolescent and early adulthood years. The cause of these neurodevelopmental impairments is multi-factorial and includes patient specific risk factors, cardiac anatomy and physiology as well as brain changes seen on MRI. Advances in imaging techniques have identified delayed brain development in the neonate with critical CHD as well as acquired brain injury. These abnormalities are seen even before corrective neonatal cardiac surgery. This review focuses on describing brain changes seen on MRI in neonates with CHD, risk factors for these changes and the association with neurodevelopmental outcome. There is an emerging focus on the impact of cardiovascular physiology on brain health and the complex heart-brain interplay that influences ultimate neurodevelopmental outcome in these patients.

引用

页码：776 / 782

页数：7

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