Interactions Among Non-Coding RNAs in Diabetic Nephropathy

被引：52

作者：

Loganathan, Tamil Selvi ^{[1
]}

Sulaiman, Siti Aishah ^{[1
]}

Murad, Nor Azian Abdul ^{[1
]}

Shah, Shamsul Azhar ^{[2
]}

Gafor, Abdul Halim Abdul ^{[3
]}

Jamal, Rahman ^{[1
]}

Abdullah, Noraidatulakma ^{[1
]}

机构：

[1] Univ Kebangsaan Malaysia, UKM Med Mol Biol Inst, Kuala Lumpur, Malaysia

[2] Univ Kebangsaan Malaysia, Dept Community Hlth, UKM Med Ctr, Kuala Lumpur, Malaysia

[3] Univ Kebangsaan Malaysia, UKM Med Ctr, Nephrol Unit, Fac Med, Kuala Lumpur, Malaysia

来源：

FRONTIERS IN PHARMACOLOGY | 2020年 / 11卷

关键词：

lncRNA; miRNA; circRNA; diabetic nephropathy; biomarkers; kidney disease; INDUCED PODOCYTE INJURY; PROMOTES RENAL FIBROSIS; CHRONIC HEPATITIS-C; MICRORNA BIOGENESIS; DOWN-REGULATION; CIRCULAR RNAS; MESANGIAL HYPERTROPHY; CELL-PROLIFERATION; KIDNEY INJURY; AKT KINASE;

D O I：

10.3389/fphar.2020.00191

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Diabetic Nephropathy (DN) is the most common cause of End-stage renal disease (ESRD). Although various treatments and diagnosis applications are available, DN remains a clinical and economic burden. Recent findings showed that noncoding RNAs (ncRNAs) play an important role in DN progression, potentially can be used as biomarkers and therapeutic targets. NcRNAs refers to the RNA species that do not encode for any protein, and the most known ncRNAs are the microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs). Dysregulation of these ncRNAs was reported before in DN patients and animal models of DN. Importantly, there are some interactions between these ncRNAs to regulate the crucial steps in DN progression. Here, we aimed to discuss the reported ncRNAs in DN and their interactions with critical genes in DN progression. Elucidating these ncRNAs regulatory network will allow for a better understanding of the molecular mechanisms in DN and how they can act as new biomarkers for DN and also as the potential targets for treatment.

引用

页数：19

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