Decrease in sweet taste in rats after gastric bypass surgery

被引：52

作者：

Tichansky, David S. ^{[1
]}

Glatt, A. Rebecca ^{[2
]}

Madan, Atul K. ^{[3
]}

Harper, Jason ^{[4
]}

Tokita, Kenichi ^{[2
]}

Boughter, John D. ^{[2
]}

机构：

[1] Thomas Jefferson Univ, Dept Surg, Philadelphia, PA 19107 USA

[2] Univ Tennessee, Ctr Hlth Sci, Dept Anat & Neurobiol, Memphis, TN 38163 USA

[3] Beverly Hills Surg Ctr, Los Angeles, CA USA

[4] Paris Surg Specialists, Paris, TN USA

来源：

SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES | 2011年 / 25卷 / 04期

关键词：

Behavior; Rats; RYGB; Sucrose; Taste; WEIGHT-LOSS; CHORDA-TYMPANI; PARABRACHIAL NUCLEUS; NEURAL RESPONSES; FOOD-INTAKE; OBESE RAT; MODEL; MECHANISMS; PATTERNS; BEHAVIOR;

D O I：

10.1007/s00464-010-1335-0

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

The literature contains evidence that Roux-en-Y gastric bypass (RYGB) surgery has an effect in humans on taste and preference for carbohydrate-rich foods. This study tested the hypothesis that RYGB affects sweet taste behavior using a rat model. Male Sprague-Dawley rats underwent either RYGB or sham surgery. Then 4 weeks after surgery, the rats were given taste-salient, brief-access lick tests with a series of sucrose concentrations. The RYGB rats, but not the sham rats, lost weight over the 5-week postoperative period. The RYGB rats showed a significant decrease in mean licks for the highest concentration of sucrose (0.25-1.0 mol/l) but not for the low concentrations of sucrose or water. The findings showed that RYGB surgery affected sweet taste behavior in rats, with postsurgical rats having lower sensitivity or avidity for sucrose than sham-treated control rats. This finding is similar to human reports that sweet taste and preferences for high-caloric foods are altered after bypass surgery.

引用

页码：1176 / 1181

页数：6

共 36 条

[21] TASTE ACUITY OF THE MORBIDLY OBESE BEFORE AND AFTER GASTRIC BYPASS-SURGERY
SCRUGGS, DM
BUFFINGTON, C
COWAN, GSM
[J]. OBESITY SURGERY, 1994, 4 (01) : 24 - 28
[22] Leptin modulates behavioral responses to sweet substances by influencing peripheral taste structures
Shigemura, N
Ohta, R
Kusakabe, Y
Miura, H
Hino, A
Koyano, K
Nakashima, K
Ninomiya, Y
[J]. ENDOCRINOLOGY, 2004, 145 (02) : 839 - 847
[23] Enhanced responses of the chorda tympani nerve to sugars in the ventromedial hypothalamic obese rat
Shimizu, Y
Yamazaki, M
Nakanishi, K
Sakurai, M
Sanada, A
Takewaki, T
Tonosaki, K
[J]. JOURNAL OF NEUROPHYSIOLOGY, 2003, 90 (01) : 128 - 133
[24] Neuropeptides modulate rat chorda tympani responses
Simon, SA
Liu, LJ
Erickson, RP
[J]. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2003, 284 (06) : R1494 - R1505
[25] SMITH JC, 1988, BEIDLER S TASTE SMEL, P205
[26] Linking peripheral taste processes to behavior
Spector, Alan C.
Glendinning, John I.
[J]. CURRENT OPINION IN NEUROBIOLOGY, 2009, 19 (04) : 370 - 377
[27] St John SJ, 2008, SENSES COMPREHENSIVE, P409
[28] STEARNS AT, 2009, AM J PHYSIOL-GASTR L, DOI DOI 10.1152/AJPGI.00253.20090193-1857/09.SEPTEMBER
[29] Roux-en-Y Gastric Bypass Enhances Energy Expenditure and Extends Lifespan in Diet-induced Obese Rats
Stylopoulos, Nicholas
Hoppin, Alison G.
Kaplan, Lee M.
[J]. OBESITY, 2009, 17 (10) : 1839 - 1847
[30] SUGARMAN HJ, 1987, ANN SURG, V205, P613

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