Characteristics of HLA-E Restricted T-Cell Responses and Their Role in Infectious Diseases

被引：65
作者：
Joosten, Simone A. [1 ]
Sullivan, Lucy C. [2 ]
Ottenhoff, Tom H. M. [1 ]
机构：
[1] Leiden Univ, Dept Infect Dis, Med Ctr, NL-2333 ZA Leiden, Netherlands
[2] Univ Melbourne, Dept Microbiol & Immunol, Peter Doherty Inst Infect & Immun, Melbourne, Vic 3010, Australia
来源：
JOURNAL OF IMMUNOLOGY RESEARCH | 2016年 / 2016卷
关键词：
PEPTIDE-BINDING-SPECIFICITY; HUMAN CYTOMEGALOVIRUS; E EXPRESSION; E GENE; ANTIGEN; RECOGNITION; IDENTIFICATION; LYMPHOCYTES; SUBSET; TUBERCULOSIS;
D O I：
10.1155/2016/2695396
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Human HLA-E can, in addition to self-antigens, also present pathogen-derived sequences, which elicit specific T-cell responses. T-cells recognize their antigen presented by HLA-E highly specifically and have unique functional and phenotypical properties. Pathogen specific HLA-E restricted CD8(+) T-cells are an interesting new player in the field of immunology. Future work should address their exact roles and relative contributions in the immune response against infectious diseases.
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页数：11
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