Roles of glia-derived extracellular vesicles in central nervous system diseases: an update

被引：1
|
作者：
Sun, Hao [1 ]
Su, Xiaojuan [1 ]
Li, Shiping [1 ]
Mu, Dezhi [1 ]
Qu, Yi [1 ]
机构：
[1] Sichuan Univ, West China Univ Hosp 2, Dept Pediat,Minist Educ, Key Lab Birth Defects & Related Dis Women & Child, Chengdu 610041, Peoples R China
来源：
REVIEWS IN THE NEUROSCIENCES | 2021年 / 32卷 / 08期
基金：
中国国家自然科学基金;
关键词：
central nervous system; extracellular vesicles; glia; ALPHA-SYNUCLEIN; ALZHEIMERS-DISEASE; AMYLOID-BETA; PARKINSONS-DISEASE; MULTIPLE-SCLEROSIS; SECRETE EXOSOMES; MICROGLIA; ASTROCYTES; GLIOMA; MICROVESICLES;
D O I：
10.1515/revneuro-2020-0144
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Extracellular vesicles (EVs) are a heteroge-neous group of cell-derived membranous vesicles secreted by various cells in the extracellular space. Accumulating evidence shows that EVs regulate cell-to -cell communication and signaling in the pathological processes of various diseases by carrying proteins, lipids, and nucleic acids to recipient cells. Glia-derived EVs act as a double-edged sword in the pathogenesis of central nervous system (CNS) diseases. They may be vectors for the spread of diseases or act as effective clearance sys-tems to protect tissues. In this review, we summarize recent studies on glia-derived EVs with a focus on their relationships with CNS diseases.
引用
收藏
页码：833 / 849
页数：17
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