Roles of glia-derived extracellular vesicles in central nervous system diseases: an update

被引：1
作者：
Sun, Hao [1 ]
Su, Xiaojuan [1 ]
Li, Shiping [1 ]
Mu, Dezhi [1 ]
Qu, Yi [1 ]
机构：
[1] Sichuan Univ, West China Univ Hosp 2, Dept Pediat,Minist Educ, Key Lab Birth Defects & Related Dis Women & Child, Chengdu 610041, Peoples R China
来源：
REVIEWS IN THE NEUROSCIENCES | 2021年 / 32卷 / 08期
基金：
中国国家自然科学基金;
关键词：
central nervous system; extracellular vesicles; glia; ALPHA-SYNUCLEIN; ALZHEIMERS-DISEASE; AMYLOID-BETA; PARKINSONS-DISEASE; MULTIPLE-SCLEROSIS; SECRETE EXOSOMES; MICROGLIA; ASTROCYTES; GLIOMA; MICROVESICLES;
D O I：
10.1515/revneuro-2020-0144
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Extracellular vesicles (EVs) are a heteroge-neous group of cell-derived membranous vesicles secreted by various cells in the extracellular space. Accumulating evidence shows that EVs regulate cell-to -cell communication and signaling in the pathological processes of various diseases by carrying proteins, lipids, and nucleic acids to recipient cells. Glia-derived EVs act as a double-edged sword in the pathogenesis of central nervous system (CNS) diseases. They may be vectors for the spread of diseases or act as effective clearance sys-tems to protect tissues. In this review, we summarize recent studies on glia-derived EVs with a focus on their relationships with CNS diseases.
引用
收藏
页码：833 / 849
页数：17
相关论文
共 175 条
  • [21] TNFα and IL-1β modify the miRNA cargo of astrocyte shed extracellular vesicles to regulate neurotrophic signaling in neurons
    Chaudhuri, Amrita Datta
    Dastgheyb, Raha M.
    Yoo, Seung-Wan
    Trout, Amanda
    Talbot, C. Conover, Jr.
    Hao, Haiping
    Witwer, Kenneth W.
    Haughey, Norman J.
    [J]. CELL DEATH & DISEASE, 2018, 9
  • [22] Increased Circulating Exosomal miRNA-223 Is Associated with Acute Ischemic Stroke
    Chen, Yajing
    Song, Yaying
    Huang, Jun
    Qu, Meijie
    Zhang, Yu
    Geng, Jieli
    Zhang, Zhijun
    Liu, Jianrong
    Yang, Guo-Yuan
    [J]. FRONTIERS IN NEUROLOGY, 2017, 8
  • [23] α-Synuclein-carrying extracellular vesicles in Parkinson's disease: deadly transmitters
    Chistiakov, Dimitry A.
    Chistiakov, Alexander A.
    [J]. ACTA NEUROLOGICA BELGICA, 2017, 117 (01) : 43 - 51
  • [24] The roles of macrophages and microglia in multiple sclerosis and experimental autoimmune encephalomyelitis
    Chu, Fengna
    Shi, Mingchao
    Zheng, Chao
    Shen, Donghui
    Zhu, Jie
    Zheng, Xiangyu
    Cui, Li
    [J]. JOURNAL OF NEUROIMMUNOLOGY, 2018, 318 : 1 - 7
  • [25] Neuroimmune Crosstalk through Extracellular Vesicles in Health and Disease
    Delpech, Jean-Christophe
    Herron, Shawn
    Botros, Mina B.
    Ikezu, Tsuneya
    [J]. TRENDS IN NEUROSCIENCES, 2019, 42 (05) : 361 - 372
  • [26] Immunopathology of multiple sclerosis
    Dendrou, Calliope A.
    Fugger, Lars
    Friese, Manuel A.
    [J]. NATURE REVIEWS IMMUNOLOGY, 2015, 15 (09) : 545 - 558
  • [27] Senescence and extracellular vesicles: novel partners in vascular amyloidosis
    Whitehead, Meredith
    Antonazzi, Marco
    Shanahan, Catherine M.
    [J]. AGING-US, 2023, 15 (05): : 1232 - 1234
  • [28] Diwanji TP, 2017, ADOLESC HEALTH MED T, V8, P99, DOI 10.2147/AHMT.S53391
  • [29] ATP Modifies the Proteome of Extracellular Vesicles Released by Microglia and Influences Their Action on Astrocytes
    Drago, Francesco
    Lombardi, Marta
    Prada, Ilaria
    Gabrielli, Martina
    Joshi, Pooja
    Cojoc, Dan
    Franck, Julien
    Fournier, Isabelle
    Vizioli, Jacopo
    Verderio, Claudia
    [J]. FRONTIERS IN PHARMACOLOGY, 2017, 8
  • [30] Molecular Control of Oligodendrocyte Development
    Elbaz, Benayahu
    Popko, Brian
    [J]. TRENDS IN NEUROSCIENCES, 2019, 42 (04) : 263 - 277
12345678910