Roles of glia-derived extracellular vesicles in central nervous system diseases: an update

被引：1

作者：

Sun, Hao ^{[1
]}

Su, Xiaojuan ^{[1
]}

Li, Shiping ^{[1
]}

Mu, Dezhi ^{[1
]}

Qu, Yi ^{[1
]}

机构：

[1] Sichuan Univ, West China Univ Hosp 2, Dept Pediat,Minist Educ, Key Lab Birth Defects & Related Dis Women & Child, Chengdu 610041, Peoples R China

来源：

REVIEWS IN THE NEUROSCIENCES | 2021年 / 32卷 / 08期

基金：

中国国家自然科学基金;

关键词：

central nervous system; extracellular vesicles; glia; ALPHA-SYNUCLEIN; ALZHEIMERS-DISEASE; AMYLOID-BETA; PARKINSONS-DISEASE; MULTIPLE-SCLEROSIS; SECRETE EXOSOMES; MICROGLIA; ASTROCYTES; GLIOMA; MICROVESICLES;

D O I：

10.1515/revneuro-2020-0144

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Extracellular vesicles (EVs) are a heteroge-neous group of cell-derived membranous vesicles secreted by various cells in the extracellular space. Accumulating evidence shows that EVs regulate cell-to -cell communication and signaling in the pathological processes of various diseases by carrying proteins, lipids, and nucleic acids to recipient cells. Glia-derived EVs act as a double-edged sword in the pathogenesis of central nervous system (CNS) diseases. They may be vectors for the spread of diseases or act as effective clearance sys-tems to protect tissues. In this review, we summarize recent studies on glia-derived EVs with a focus on their relationships with CNS diseases.

引用

页码：833 / 849

页数：17

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