Synthesis, Characterization and Biological Evaluation of New 5-aryl-4-methyl-2-[para-(phenylsulfonyl)phenyl]oxazoles

被引：0
|
作者：
Apostol, Theodora-Venera [1 ]
Draghici, Constantin [2 ]
Dinu, Mihaela [2 ]
Barbuceanu, Stefania-Felicia [1 ]
Socea, Laura Ileana [1 ]
Saramet, Ioana [1 ]
机构：
[1] Carol Davila Univ Med & Pharm, Fac Pharm, Dept Organ Chem, Bucharest 020956, Romania
[2] Acad Romana, Ctr Organ Chem CD Nenitzescu, Bucharest 060023, Romania
来源：
REVISTA DE CHIMIE | 2011年 / 62卷 / 02期
关键词：
N-acyl-aminoacid; alpha-acylaminoketone; 1,3-oxazole; 5(4H)-oxazolone; acylaminoacylation; plant-growth regulating effect; ACID AMIDE HYDROLASE; FRIEDEL-CRAFTS REACTION; OXAZOLE SYNTHESIS; THIAZOLE SYNTHESIS; ANTIBACTERIAL ACTIVITY; AROMATIC-HYDROCARBONS; ANTIFUNGAL ACTIVITY; P38; INHIBITORS; AMINO-ACIDS; AMINOKETONE;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Acylaminoacylation of aromatic hydrocarbons (benzene, toluene, m-xylene) with 4-methyl-2-[4-(phenylsulfonyl)phenyl]oxazol-5(4H)-one in the presence of anhydrous aluminum chloride afforded 2-aza-1,4-diaryl-3-methyl-1,4-butanediones. These new intermediates were cyclized under the action of phosphorus oxychloride to the corresponding 5-aryl-4-methyl-2-[4-(phenylsulfonyl)phenyl]oxazoles. The structures of newly synthesized compounds were confirmed by elemental analysis, FT-IR, UV, H-1- and C-13-NMR. The plant-growth regulating effects of the new compounds were examined. From this biological activity evaluation, it resulted that most compounds shown a weak stimulatory activity at low concentrations.
引用
收藏
页码：142 / 148
页数：7
相关论文
共 50 条
  • [21] Synthesis, Characterization and Chelating Properties of 4-Butyrylsemicarbazone-1-phenyl-3-methyl-2-pyrazolin-5-one
    Patel, J. D.
    Shah, P. J.
    E-JOURNAL OF CHEMISTRY, 2010, 7 (02) : 357 - 362
  • [22] Synthesis and antibacterial activity of 2-aryl-3-(4′-trifluoro methyl phenyl)-4-oxo-thiazolidines
    Solankee, A
    Kapadia, K
    Lad, S
    Thakor, I
    Patel, J
    ASIAN JOURNAL OF CHEMISTRY, 2003, 15 (02) : 755 - 758
  • [23] Regio Selective Synthesis of Pyrazole Derivatives of 5-Chloro-2-Methoxy Phenyl Hydrazide and Their Biological Evaluation
    Bavishi, Abhay
    Vala, Hardev
    Swami, Sagar
    Thakrar, Shailesh
    Shah, Anamik
    Sarkar, Dhiman
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2025,
  • [24] Synthesis and biological evaluation of 2-phenyl-4-aminoquinolines as potential antifungal agents
    Rui Yang
    Wenhao Du
    Huan Yuan
    Tianhong Qin
    Renxiao He
    Yanni Ma
    Haiying Du
    Molecular Diversity, 2020, 24 : 1065 - 1075
  • [25] Synthesis and biological evaluation of 2-phenyl-4-aminoquinolines as potential antifungal agents
    Yang, Rui
    Du, Wenhao
    Yuan, Huan
    Qin, Tianhong
    He, Renxiao
    Ma, Yanni
    Du, Haiying
    MOLECULAR DIVERSITY, 2020, 24 (04) : 1065 - 1075
  • [26] Synthesis and Biological Activity Evaluation of Novel 5-Methyl-7-phenyl-3H-thiazolo[4,5-b]pyridin-2-ones
    Lozynskyi, Andrii
    Konechnyi, Yulian
    Senkiv, Julia
    Yushyn, Ihor
    Khyluk, Dmytro
    Karpenko, Olexandr
    Shepeta, Yulia
    Lesyk, Roman
    SCIENTIA PHARMACEUTICA, 2021, 89 (04)
  • [27] Synthesis, Characterization of Some Metal Complexes of 4-Acetylsemicarbazone-1-phenyl-3-methyl-2-pyrazolin-5-one
    Patel, J. D.
    Shah, P. J.
    ASIAN JOURNAL OF CHEMISTRY, 2010, 22 (04) : 3069 - 3075
  • [28] Design, synthesis, and biological evaluation of new 1-aryl-4-(β-D-fructopyranos-3-O-yl)methyl-1H-1,2,3-triazole derivatives
    Dinesh Kumar Reddy Vennam
    Ranjith Kumar Thatipamula
    Sharath Babu Haridasyam
    Shiva Kumar Koppula
    Chemistry of Heterocyclic Compounds, 2018, 54 : 630 - 637
  • [29] Synthesis and Fungicidal Activities of 2-Substituted-4-methyl-5-aryl-2H-1,2,3-triazole Derivatives
    Bo, Rui
    Lei, Sufang
    Li, Sunyong
    Li, Datuan
    Li, Yuanxiang
    INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2019, 29 (01) : 87 - 92
  • [30] Design, Synthesis, and Biological Evaluation of New 1-(Aryl-1H-pyrrolyl)(phenyl)methyl-1H-innidazole Derivatives as Antiprotozoal Agents
    Saccoliti, Francesco
    Madia, Valentina Noemi
    Tudino, Valeria
    De Leo, Alessandro
    Pescatori, Luca
    Messore, Antonella
    De Vita, Daniela
    Scipione, Luigi
    Brun, Reto
    Kaiser, Marcel
    Maser, Pascal
    Calvet, Claudia M.
    Jennings, Gareth K.
    Podust, Larissa M.
    Pepe, Giacomo
    Cirilli, Roberto
    Faggi, Cristina
    Di Marco, Annalise
    Battista, Maria Rosaria
    Summa, Vincenzo
    Costi, Roberta
    Di Santo, Roberto
    JOURNAL OF MEDICINAL CHEMISTRY, 2019, 62 (03) : 1330 - 1347
12345