Liquid forms of pharmaceutical co-crystals: exploring the boundaries of salt formation

被引：108

作者：

Bica, Katharina ^{[1
,2
]}

Shamshina, Julia ^{[3
,4
]}

Hough, Whitney L. ^{[3
,4
]}

MacFarlane, Douglas R. ^{[5
]}

Rogers, Robin D. ^{[2
,3
,4
]}

机构：

[1] Vienna Univ Technol, Inst Appl Synthet Chem, A-1060 Vienna, Austria

[2] Queens Univ Belfast, QUILL, Sch Chem & Chem Engn, Belfast BT9 5AG, Antrim, North Ireland

[3] Univ Alabama, Dept Chem, Tuscaloosa, AL 35487 USA

[4] Univ Alabama, Ctr Green Mfg, Tuscaloosa, AL 35487 USA

[5] Monash Univ, Sch Chem, Clayton, Vic 3800, Australia

来源：

CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 08期

关键词：

IONIC LIQUIDS; CHOLINE CHLORIDE; DESIGN; ACID;

D O I：

10.1039/c0cc04485g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We present evidence of hydrogen bond formation, not salt formation, as the driving force in the liquefaction of a solid pharmaceutical in the form of a neutral acid-base complex, as exemplified by the liquid formed from a mixture of the local anesthetic lidocaine with fatty acids; these complexes exist at the boundary between simple eutectics and partially ionised ionic liquids.

引用

页码：2267 / 2269

页数：3

共 26 条

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