Blood-brain barrier dysfunction, seizures and epilepsy

被引：167

作者：

van Vliet, E. A. ^{[1
]}

Aronica, E. ^{[1
]}

Gorter, J. A. ^{[2
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, Dept Neuro Pathol, NL-1105 AZ Amsterdam, Netherlands

[2] Univ Amsterdam, Ctr Neurosci, Swammerdam Inst Life Sci, NL-1105 AZ Amsterdam, Netherlands

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2015年 / 38卷

关键词：

Blood-brain barrier; Temporal lobe epilepsy; Traumatic brain injury; Epileptogenesis; Albumin; LITHIUM-PILOCARPINE MODEL; HYPERTHERMIA-INDUCED SEIZURES; STATUS-EPILEPTICUS; TUBEROUS SCLEROSIS; MAMMALIAN TARGET; SPREADING DEPOLARIZATION; SERUM-ALBUMIN; FUNCTIONAL CONSEQUENCES; SYNAPTIC-TRANSMISSION; SIGNALING PATHWAY;

D O I：

10.1016/j.semcdb.2014.10.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The blood-brain barrier (BBB) is a dynamic and complex system which separates the brain from the blood. It helps to maintain the homeostasis of the brain, which is essential for normal neuronal functioning. BBB function is impaired in several neurological diseases, including epilepsy in which it may lead to abnormal and excessive neuronal firing. In this review we will discuss how BBB dysfunction can affect neuronal function and how this can lead to seizures and epilepsy. We will also summarize new therapies that aim to preserve or restore BBB function in order to prevent or reduce epileptogenesis. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：26 / 34

页数：9

共 107 条

[91] Longitudinal assessment of blood-brain barrier leakage during epileptogenesis in rats. A quantitative MRI study [J].

van Vliet, E. A. ;

Otte, W. M. ;

Gorter, J. A. ;

Dijkhuizen, R. M. ;

Wadman, W. J. .

NEUROBIOLOGY OF DISEASE, 2014, 63 :74-84

[92] Inhibition of mammalian target of rapamycin reduces epileptogenesis and blood-brain barrier leakage but not microglia activation [J].

van Vliet, Erwin A. ;

Forte, Grazia ;

Holtman, Linda ;

den Burger, Jeroen C. G. ;

Sinjewel, Arno ;

de Vries, Helga E. ;

Aronica, Eleonora ;

Gorter, Jan A. .

EPILEPSIA, 2012, 53 (07) :1254-1263

[93] COX-2 inhibition controls P-glycoprotein expression and promotes brain delivery of phenytoin in chronic epileptic rats [J].

van Vliet, Erwin A. ;

Zibell, Guido ;

Pekcec, Anton ;

Schlichtiger, Juli ;

Edelbroek, Peter M. ;

Holtman, Linda ;

Aronica, Eleonora ;

Gorter, Jan A. ;

Potschka, Heidrun .

NEUROPHARMACOLOGY, 2010, 58 (02) :404-412

[94] SELF-SUSTAINING LIMBIC STATUS EPILEPTICUS .1. ACUTE AND CHRONIC CEREBRAL METABOLIC STUDIES - LIMBIC HYPERMETABOLISM AND NEOCORTICAL HYPOMETABOLISM [J].

VANLANDINGHAM, KE ;

LOTHMAN, EW .

NEUROLOGY, 1991, 41 (12) :1942-1949

[95] Epilepsy and brain inflammation [J].

Vezzani, Annamaria ;

Aronica, Eleonora ;

Mazarati, Andrey ;

Pittman, Quentin J. .

EXPERIMENTAL NEUROLOGY, 2013, 244 :11-21

[96]

Vezzani A, 2011, BIOMARK MED, V5, P607, DOI [10.2217/BMM.11.61, 10.2217/bmm.11.61]

[97] The role of inflammation in epilepsy [J].

Vezzani, Annamaria ;

French, Jacqueline ;

Bartfai, Tamas ;

Baram, Tallie Z. .

NATURE REVIEWS NEUROLOGY, 2011, 7 (01) :31-40

[98] The impact of astrocytic gap junctional coupling on potassium buffering in the hippocampus [J].

Wallraff, Anke ;

Koehling, Rudiger ;

Heinemann, Uwe ;

Theis, Martin ;

Willecke, Klaus ;

Steinhaeuser, Christian .

JOURNAL OF NEUROSCIENCE, 2006, 26 (20) :5438-5447

[99]

Weissberg I, 2011, EPILEPSY RES TREAT, V2011, DOI [DOI 10.1155/2011/143908, 10.1155/2011/143908]

[100] ANTI-PEROXIDANT PRETREATMENT AND IRON-INDUCED EPILEPTIFORM DISCHARGES IN THE RAT - EEG AND HISTOPATHOLOGIC STUDIES [J].

WILLMORE, LJ ;

RUBIN, JJ .

NEUROLOGY, 1981, 31 (01) :63-69

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