Blood-brain barrier dysfunction, seizures and epilepsy

被引：167
作者：
van Vliet, E. A. [1 ]
Aronica, E. [1 ]
Gorter, J. A. [2 ]
机构：
[1] Univ Amsterdam, Acad Med Ctr, Dept Neuro Pathol, NL-1105 AZ Amsterdam, Netherlands
[2] Univ Amsterdam, Ctr Neurosci, Swammerdam Inst Life Sci, NL-1105 AZ Amsterdam, Netherlands
来源：
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2015年 / 38卷
关键词：
Blood-brain barrier; Temporal lobe epilepsy; Traumatic brain injury; Epileptogenesis; Albumin; LITHIUM-PILOCARPINE MODEL; HYPERTHERMIA-INDUCED SEIZURES; STATUS-EPILEPTICUS; TUBEROUS SCLEROSIS; MAMMALIAN TARGET; SPREADING DEPOLARIZATION; SERUM-ALBUMIN; FUNCTIONAL CONSEQUENCES; SYNAPTIC-TRANSMISSION; SIGNALING PATHWAY;
D O I：
10.1016/j.semcdb.2014.10.003
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The blood-brain barrier (BBB) is a dynamic and complex system which separates the brain from the blood. It helps to maintain the homeostasis of the brain, which is essential for normal neuronal functioning. BBB function is impaired in several neurological diseases, including epilepsy in which it may lead to abnormal and excessive neuronal firing. In this review we will discuss how BBB dysfunction can affect neuronal function and how this can lead to seizures and epilepsy. We will also summarize new therapies that aim to preserve or restore BBB function in order to prevent or reduce epileptogenesis. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：26 / 34
页数：9
相关论文
共 107 条
[1]   Structure and function of the blood-brain barrier [J].
Abbott, N. Joan ;
Patabendige, Adjanie A. K. ;
Dolman, Diana E. M. ;
Yusof, Siti R. ;
Begley, David J. .
NEUROBIOLOGY OF DISEASE, 2010, 37 (01) :13-25
[2]   Inflammatory mediators and modulation of blood-brain barrier permeability [J].
Abbott, NJ .
CELLULAR AND MOLECULAR NEUROBIOLOGY, 2000, 20 (02) :131-147
[3]   Effects of levetiracetam on blood-brain barrier disturbances following hyperthermia-induced seizures in rats with cortical dysplasia [J].
Ahishali, Bulent ;
Kaya, Mehmet ;
Orhan, Nurcan ;
Arican, Nadir ;
Ekizoglu, Oguzhan ;
Elmas, Imdat ;
Kucuk, Mutlu ;
Kemikler, Gonul ;
Kalayci, Rivaze ;
Gurses, Candan .
LIFE SCIENCES, 2010, 87 (19-22) :609-619
[4]   Expression pattern of miR-146a, an inflammation-associated microRNA, in experimental and human temporal lobe epilepsy [J].
Aronica, E. ;
Fluiter, K. ;
Iyer, A. ;
Zurolo, E. ;
Vreijling, J. ;
van Vliet, E. A. ;
Baayen, J. C. ;
Gorter, J. A. .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2010, 31 (06) :1100-1107
[5]   Losartan Prevents Acquired Epilepsy via TGF-β Signaling Suppression [J].
Bar-Klein, Guy ;
Cacheaux, Luisa P. ;
Kamintsky, Lyn ;
Prager, Ofer ;
Weissberg, Itai ;
Schoknecht, Karl ;
Cheng, Paul ;
Kim, Soo Young ;
Wood, Lydia ;
Heinemann, Uwe ;
Kaufer, Daniela ;
Friedman, Alon .
ANNALS OF NEUROLOGY, 2014, 75 (06) :864-875
[6]   Inflammatory processes in cortical tubers and subependymal giant cell tumors of tuberous sclerosis complex [J].
Boer, K. ;
Jansen, F. ;
Nellist, M. ;
Redeker, S. ;
van den Ouweland, A. M. W. ;
Spliet, W. G. M. ;
van Nieuwenhuizen, O. ;
Troost, D. ;
Crino, P. B. ;
Aronica, E. .
EPILEPSY RESEARCH, 2008, 78 (01) :7-21
[7]  
BOLWIG TG, 1977, ACTA NEUROL SCAND, V56, P335
[8]   Alterations in miRNA Levels in the Dentate Gyrus in Epileptic Rats [J].
Bot, Anna Maria ;
Debski, Konrad Jozef ;
Lukasiuk, Katarzyna .
PLOS ONE, 2013, 8 (10)
[9]   Mapping of the progressive metabolic changes occurring during the development of hippocampal sclerosis in a model of mesial temporal lobe epilepsy [J].
Bouilleret, V ;
Boyet, S ;
Marescaux, C ;
Nehlig, A .
BRAIN RESEARCH, 2000, 852 (02) :255-262
[10]   Albumin is taken up by hippocampal NG2 cells and astrocytes and decreases gap junction coupling [J].
Braganza, Oliver ;
Bedner, Peter ;
Huettmann, Kerstin ;
von Staden, Elena ;
Friedman, Alon ;
Seifert, Gerald ;
Steinhaeuser, Christian .
EPILEPSIA, 2012, 53 (11) :1898-1906
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