Collagen-targeted MRI contrast agent for molecular Imaging of fibrosis

被引：194
|
作者：
Caravan, Peter
Das, Biplab
Dumas, Stephane
Epstein, Frederick H.
Helm, Patrick A.
Jacques, Vincent
Koerner, Steffi
Kolodziej, Andrew
Shen, Luhua
Sun, Wei-Chuan
Zhang, Zhaoda
机构：
[1] EPIX Pharmaceut Inc, Lexington, MA 02421 USA
[2] Massachusetts Gen Hosp, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA
[3] Univ Virginia, Dept Radiol, Charlottesville, VA 22908 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 43期
关键词：
D O I：
10.1002/anie.200700700
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Figure Presented) A cyclic peptide specific for type I collagen is derivatized with three {Cd(dtpa)} moieties to create a molecular MRI contrast agent for fibrosis imaging. In a mouse model of myocardial infarction (heart attack), collagen levels are elevated in the infarct zone. MRI after injection of the contrast agent selectively enhances and delineates the infarct zone (see preinjection and postinjection images); dtpa = diethylenetriaminepentaacetate. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：8171 / 8173
页数：3
相关论文
共 50 条
  • [21] Biocompatible Nanocomplexes for Molecular Targeted MRI Contrast Agent
    Chen, Zhijin
    Yu, Dexin
    Wang, Shaojie
    Zhang, Na
    Ma, Chunhong
    Lu, Zaijun
    NANOSCALE RESEARCH LETTERS, 2009, 4 (07): : 618 - 626
  • [22] Biocompatible Nanocomplexes for Molecular Targeted MRI Contrast Agent
    Zhijin Chen
    Dexin Yu
    Shaojie Wang
    Na Zhang
    Chunhong Ma
    Zaijun Lu
    Nanoscale Research Letters, 4
  • [23] Molecular MRI of Liver Fibrosis by a Peptide-Targeted Contrast Agent in an Experimental Mouse Model
    Chow, April M.
    Tan, Mingqian
    Gao, Darwin S.
    Fan, Shu Juan
    Cheung, Jerry S.
    Qiao, Zhongwei
    Man, Kwan
    Lu, Zheng-Rong
    Wu, Ed X.
    INVESTIGATIVE RADIOLOGY, 2013, 48 (01) : 46 - 54
  • [24] RETRACTION: A robust collagen-targeting MRI peptide contrast agent for in vivo imaging of hepatic fibrosis
    Liu, Zhao
    Nian, Linge
    Cai, Xiangdong
    Hu, Yue
    Lei, Junqiang
    Xiao, Jianxi
    CHEMICAL COMMUNICATIONS, 2024, 60 (85) : 12457 - 12457
  • [25] CM-101: Type I Collagen-targeted MR Imaging Probe for Detection of Liver Fibrosis
    Farrar, Christian T.
    Gale, Eric M.
    Kennan, Richard
    Ramsay, Ian
    Masia, Ricard
    Arora, Gunisha
    Looby, Kailyn
    Wei, Lan
    Kalpathy-Cramer, Jayashree
    Bunzel, Michelle M.
    Zhang, Chunlian
    Zhu, Yonghua
    Akiyama, Taro E.
    Klimas, Michael
    Pinto, Shirly
    Diyabalanage, Himashinie
    Tanabe, Kenneth K.
    Humblet, Valerie
    Fuchs, Bryan C.
    Caravan, Peter
    RADIOLOGY, 2018, 287 (02) : 581 - 589
  • [26] Fibrotic Response to Neoadjuvant Therapy Predicts Survival in Pancreatic Cancer and Is Measurable with Collagen-Targeted Molecular MRI
    Erstad, Derek J.
    Sojoodi, Mozhdeh
    Taylor, Martin S.
    Jordan, Veronica Clavijo
    Farrar, Christian T.
    Axtell, Andrea L.
    Rotile, Nicholas J.
    Jones, Chloe
    Graham-O'Regan, Katherine A.
    Ferreira, Diego S.
    Michelakos, Theodoros
    Kontos, Filippos
    Chawla, Akhil
    Li, Shen
    Ghoshal, Sarani
    Chen, Yin-Ching Iris
    Arora, Gunisha
    Humblet, Valerie
    Deshpande, Vikram
    Qadan, Motaz
    Bardeesy, Nabeel
    Ferrone, Cristina R.
    Lanuti, Michael
    Tanabe, Kenneth K.
    Caravan, Peter
    Fuchs, Bryan C.
    CLINICAL CANCER RESEARCH, 2020, 26 (18) : 5007 - 5018
  • [27] Type I Collagen-Targeted PET Imaging in Idiopathic Pulmonary Fibrosis: First-in-Human Studies
    Montesi, S. B.
    Izquierdo-Garcia, D.
    Abston, E. D.
    Desogere, P.
    Digumarthy, S.
    Seethamraju, R.
    Lanuti, M.
    Catana, C.
    Caravan, P.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2019, 199
  • [28] Collagen-targeted protein nanomicelles for the imaging of non-alcoholic steatohepatitis
    Wang, Andrew L.
    Mishkit, Orin
    Mao, Heather
    Arivazhagan, Lakshmi
    Dong, Tony
    Lee, Frances
    Bhattacharya, Aparajita
    Renfrew, P. Douglas
    Schmidt, Ann Marie
    Wadghiri, Youssef Z.
    Fisher, Edward A.
    Montclare, Jin Kim
    ACTA BIOMATERIALIA, 2024, 187 : 291 - 303
  • [29] Targeted biodegradable dendritic MRI contrast agent for enhanced tumor imaging
    Ye, Mingzhou
    Qian, Yue
    Tang, Jianbin
    Hu, Hongjie
    Sui, Meihua
    Shen, Youqing
    JOURNAL OF CONTROLLED RELEASE, 2013, 169 (03) : 239 - 245
  • [30] A Peptide Targeted Contrast Agent Specific to Fibrin-Fibronectin Complexes for Cancer Molecular Imaging with MRI
    Ye, Furong
    Jeong, Eun-Kee
    Jia, Zhanjun
    Yang, Tianxin
    Parker, Denis
    Lu, Zheng-Rong
    BIOCONJUGATE CHEMISTRY, 2008, 19 (12) : 2300 - 2303
12345