Collagen-targeted MRI contrast agent for molecular Imaging of fibrosis

被引：194
|
作者：
Caravan, Peter
Das, Biplab
Dumas, Stephane
Epstein, Frederick H.
Helm, Patrick A.
Jacques, Vincent
Koerner, Steffi
Kolodziej, Andrew
Shen, Luhua
Sun, Wei-Chuan
Zhang, Zhaoda
机构：
[1] EPIX Pharmaceut Inc, Lexington, MA 02421 USA
[2] Massachusetts Gen Hosp, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA
[3] Univ Virginia, Dept Radiol, Charlottesville, VA 22908 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 43期
关键词：
D O I：
10.1002/anie.200700700
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Figure Presented) A cyclic peptide specific for type I collagen is derivatized with three {Cd(dtpa)} moieties to create a molecular MRI contrast agent for fibrosis imaging. In a mouse model of myocardial infarction (heart attack), collagen levels are elevated in the infarct zone. MRI after injection of the contrast agent selectively enhances and delineates the infarct zone (see preinjection and postinjection images); dtpa = diethylenetriaminepentaacetate. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：8171 / 8173
页数：3
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