Potential role of cyclophilin A in regulating cytokine secretion

被引：70

作者：

Dawar, Farman Ullah ^{[1
]}

Xiong, Yang ^{[1
]}

Khattak, Muhammad Nasir Khan ^{[2
,3
]}

Li, Jun ^{[4
]}

Lin, Li ^{[1
,5
]}

Mei, Jie ^{[1
]}

机构：

[1] Huazhong Agr Univ, Coll Fisheries, 1 Shizishan St, Wuhan 430070, Hubei, Peoples R China

[2] Hazara Univ, Dept Zool, Mansehra, Khyber Pakhtunk, Pakistan

[3] Univ Sharjah, Dept Appl Biol, Coll Sci, Sharjah, U Arab Emirates

[4] Lake Super Univ, Sch Biol Sci, Sault Ste Marie, MI USA

[5] Zhongkai Univ Agr & Engn, Coll Anim Sci & Technol, Guangzhou, Guangdong, Peoples R China

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 2017年 / 102卷 / 04期

关键词：

CD147; inflammation; diseases; mechanism; CELL-SURFACE EXPRESSION; CYCLOSPORINE-A; RHEUMATOID-ARTHRITIS; PROLYL ISOMERASE; TARGET; KINASE; CD147; PATHWAY; MONOCYTES/MACROPHAGES; CALCINEURIN;

D O I：

10.1189/jlb.3RU0317-090RR

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cyclophilin A (CypA), a peptidylprolyl cis-trans isomerase, is a ubiquitous and multifunctional protein. In addition to its role as a host-cell receptor for cyclosporine A, CypA has diverse functions in inflammatory conditions and diseases. CypA secreted in response to inflammatory stimuli binds to the cell surface via its receptor CD147 and induces secretion of various inflammatory cytokines. However, silencing and inhibition of either CypA or CD147 inhibits inflammatory cytokine expression and inflammation. This report reviews the literature related to the mechanism of CypA-dependent cytokine secretion and discusses this factor as a possible therapeutic target in inflammatory diseases.

引用

页码：989 / 992

页数：4

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