Lipoperoxidation and cyclooxygenase enzyme inhibitory piperidine alkaloids from Cassia spectabilis green fruits

被引：29
|
作者：
Viegas, Claudio, Jr. [3 ,4 ]
Silva, Dulce H. S. [3 ]
Pivatto, Marcos [3 ]
de Rezende, Amanda [3 ]
Castro-Gamboa, Ian [3 ]
Bolzani, Vanderlan S. [3 ]
Nair, Muraleedharan G. [1 ,2 ]
机构：
[1] Michigan State Univ, Dept Hort, E Lansing, MI 48824 USA
[2] Michigan State Univ, Natl Food Safety & Toxicol Ctr, E Lansing, MI 48824 USA
[3] Sao Paulo State Univ, UNESP, Inst Quim, BR-14800900 Araraquara, SP, Brazil
[4] Univ Fed Alfenas, Dept Ciencias Exatas, BR-37130000 Alfenas, MG, Brazil
来源：
JOURNAL OF NATURAL PRODUCTS | 2007年 / 70卷 / 12期
关键词：
D O I：
10.1021/np070312g
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Phytochernical work in the search for bioactive metabolites from the methanolic extract of Senna spectabilis green fruits led to the isolation of a new piperidine alkaloid, (+)-3-O-feruloylcassine (1), in addition to the known (-)-spectaline (2) and (-)-3-O-acetylspectaline (3). The isolates were submitted to in vitro evaluation of lipoperoxidation (LPO) and cyclooxygenase enzymes (COX-1 and -2) inhibitory properties and showed moderate antioxidant activities (40-70%) at 100 ppm when compared to commercial standards BHT and vitamin E and moderate inhibition of COX-1 (ca. 40%) and marginal inhibition of COX-2 enzymes (< 10%) at 100 ppm when compared to nonsteroidal anti-inflammatory drugs (NSAIDs) aspirin, rofecoxib, and celecoxib, respectively.
引用
收藏
页码：2026 / 2028
页数：3
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