Wilms' tumours: about tumour suppressor genes, an oncogene and a chameleon gene

被引：190
作者：
Huff, Vicki [1 ,2 ,3 ]
机构：
[1] Univ Texas MD Anderson Canc Ctr, Dept Genet, Unit 1010, Houston, TX 77030 USA
[2] UT Houston Grad Sch Biomed Sci, Grad Program Genes & Dev, Houston, TX 77025 USA
[3] UT Houston Grad Sch Biomed Sci, Grad Program Human Mol Genet, Houston, TX 77025 USA
来源：
NATURE REVIEWS CANCER | 2011年 / 11卷 / 02期
关键词：
ACUTE MYELOID-LEUKEMIA; BECKWITH-WIEDEMANN-SYNDROME; HEMATOPOIETIC PROGENITOR CELLS; MINIMAL RESIDUAL DISEASE; EARLY KIDNEY DEVELOPMENT; WT1; MESSENGER-RNA; BETA-CATENIN; NEPHROGENIC RESTS; PROGNOSTIC-SIGNIFICANCE; WILMS-TUMOR-1; GENE;
D O I：
10.1038/nrc3002
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Genes identified as being mutated in Wilms' tumour include TP53, a classic tumour suppressor gene (TSG); CTNNB1 (encoding beta-catenin), a classic oncogene; WTX, which accumulating data indicate is a TSG; and WT1, which is inactivated in some Wilms' tumours, similar to a TSG. However, WT1 does not always conform to the TSG label, and some data indicate that WT1 enhances cell survival and proliferation, like an oncogene. Is WT1 a chameleon, functioning as either a TSG or an oncogene, depending on cellular context? Are these labels even appropriate for describing and understanding the function of WT1?
引用
收藏
页码：111 / 121
页数：11
相关论文
共 112 条
  • [81] Functional inactivation of the WTX gene is not a frequent event in Wilms' tumors
    Perotti, D.
    Gamba, B.
    Sardella, M.
    Spreafico, F.
    Terenziani, M.
    Collini, P.
    Pession, A.
    Nantron, M.
    Fossati-Bellani, F.
    Radice, P.
    [J]. ONCOGENE, 2008, 27 (33) : 4625 - 4632
  • [82] Microdeletion of target sites for insulator protein CTCF in a chromosome 11p15 imprinting center in Beckwith-Wiedemann syndrome and Wilms' tumor
    Prawitt, D
    Enklaar, T
    Gärtner-Rupprecht, B
    Spangenberg, C
    Oswald, M
    Lausch, E
    Schmidtke, P
    Reutzel, D
    Fees, S
    Lucito, R
    Korzon, M
    Brozek, L
    Limon, J
    Housman, DE
    Pelletier, J
    Zabel, B
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (11) : 4085 - 4090
  • [83] THE WILMS-TUMOR (WT1) GENE IS MUTATED IN A SECONDARY LEUKEMIA IN A WAGR PATIENT
    PRITCHARDJONES, K
    RENSHAW, J
    KINGUNDERWOOD, L
    [J]. HUMAN MOLECULAR GENETICS, 1994, 3 (09) : 1633 - 1637
  • [84] THE CANDIDATE WILMS-TUMOR GENE IS INVOLVED IN GENITOURINARY DEVELOPMENT
    PRITCHARDJONES, K
    FLEMING, S
    DAVIDSON, D
    BICKMORE, W
    PORTEOUS, D
    GOSDEN, C
    BARD, J
    BUCKLER, A
    PELLETIER, J
    HOUSMAN, D
    VANHEYNINGEN, V
    HASTIE, N
    [J]. NATURE, 1990, 346 (6280) : 194 - 197
  • [85] Evidence for a familial Wilms' tumour gene (FWT1) on chromosome 17q12-q21
    Rahman, N
    Arbour, L
    Tonin, P
    Renshaw, J
    Pelletier, J
    Baruchel, S
    PritchardJones, K
    Stratton, MR
    Narod, SA
    [J]. NATURE GENETICS, 1996, 13 (04) : 461 - 463
  • [86] RELAXATION OF IMPRINTED GENES IN HUMAN CANCER
    RAINIER, S
    JOHNSON, LA
    DOBRY, CJ
    PING, AJ
    GRUNDY, PE
    FEINBERG, AP
    [J]. NATURE, 1993, 362 (6422) : 747 - 749
  • [87] An X chromosome gene, WTX, is commonly inactivated in Wilms tumor
    Rivera, Miguel N.
    Kim, Woo Jae
    Wells, Julie
    Driscoll, David R.
    Brannigan, Brian W.
    Han, Moonjoo
    Kim, James C.
    Feinberg, Andrew P.
    Gerald, William L.
    Vargas, Sara O.
    Chin, Lynda
    Iafrate, A. John
    Bell, Daphne W.
    Haber, Daniel A.
    [J]. SCIENCE, 2007, 315 (5812) : 642 - 645
  • [88] The tumor suppressor WTX shuttles to the nucleus and modulates WT1 activity
    Rivera, Miguel N.
    Kim, Woo Jae
    Wells, Julie
    Stone, Amanda
    Burger, Alexa
    Coffman, Erik J.
    Zhang, Jianmin
    Haber, Daniel A.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (20) : 8338 - 8343
  • [89] Prognostic significance of WT1 gene expression in pediatric acute myeloid leukemia
    Rodrigues, Patricia C.
    Oliveira, Satiro N.
    Viana, Marcos B.
    Matsuda, Eduardo I.
    Nowill, Alexandre E.
    Brandalise, Silvia R.
    Yunes, Jose A.
    [J]. PEDIATRIC BLOOD & CANCER, 2007, 49 (02) : 133 - 138
  • [90] Twenty-four new cases of WT1 germline mutations and review of the literature:: Genotype/phenotype correlations for Wilms tumor development
    Royer-Pokora, B
    Beier, M
    Henzler, M
    Alam, R
    Schumacher, V
    Weirich, A
    Huff, V
    [J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART A, 2004, 127A (03) : 249 - 257
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