Wilms' tumours: about tumour suppressor genes, an oncogene and a chameleon gene

被引：190
作者：
Huff, Vicki [1 ,2 ,3 ]
机构：
[1] Univ Texas MD Anderson Canc Ctr, Dept Genet, Unit 1010, Houston, TX 77030 USA
[2] UT Houston Grad Sch Biomed Sci, Grad Program Genes & Dev, Houston, TX 77025 USA
[3] UT Houston Grad Sch Biomed Sci, Grad Program Human Mol Genet, Houston, TX 77025 USA
来源：
NATURE REVIEWS CANCER | 2011年 / 11卷 / 02期
关键词：
ACUTE MYELOID-LEUKEMIA; BECKWITH-WIEDEMANN-SYNDROME; HEMATOPOIETIC PROGENITOR CELLS; MINIMAL RESIDUAL DISEASE; EARLY KIDNEY DEVELOPMENT; WT1; MESSENGER-RNA; BETA-CATENIN; NEPHROGENIC RESTS; PROGNOSTIC-SIGNIFICANCE; WILMS-TUMOR-1; GENE;
D O I：
10.1038/nrc3002
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Genes identified as being mutated in Wilms' tumour include TP53, a classic tumour suppressor gene (TSG); CTNNB1 (encoding beta-catenin), a classic oncogene; WTX, which accumulating data indicate is a TSG; and WT1, which is inactivated in some Wilms' tumours, similar to a TSG. However, WT1 does not always conform to the TSG label, and some data indicate that WT1 enhances cell survival and proliferation, like an oncogene. Is WT1 a chameleon, functioning as either a TSG or an oncogene, depending on cellular context? Are these labels even appropriate for describing and understanding the function of WT1?
引用
收藏
页码：111 / 121
页数：11
相关论文
共 112 条
  • [71] MIWA H, 1992, LEUKEMIA, V6, P405
  • [72] WT1 induction of mitogen-activated protein kinase phosphatase 3 represents a novel mechanism of growth suppression
    Morrison, Debra J.
    Kim, Marianne K. H.
    Berkofsky-Fessier, Windy
    Licht, Jonathan D.
    [J]. MOLECULAR CANCER RESEARCH, 2008, 6 (07) : 1225 - 1231
  • [73] A mammal-specific Exon of WT1 is not required for development or fertility
    Natoli, TA
    McDonald, A
    Alberta, JA
    Taglienti, ME
    Housman, DE
    Kreidberg, JA
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (12) : 4433 - 4438
  • [74] AML1-ETO rapidly induces acute myeloblastic leukemia in cooperation with the Wilms tumor gene, WT1.
    Nishida, S
    Hosen, N
    Shirakata, T
    Kanato, K
    Yanagihara, M
    Nakatsuka, S
    Hoshida, Y
    Nakazawa, T
    Harada, Y
    Tatsumi, N
    Tsuboi, A
    Kawakami, M
    Oka, Y
    Oji, Y
    Aozasa, K
    Kawase, I
    Sugiyama, H
    [J]. BLOOD, 2006, 107 (08) : 3303 - 3312
  • [75] RELAXATION OF INSULIN-LIKE GROWTH FACTOR-II GENE IMPRINTING IMPLICATED IN WILMS-TUMOR
    OGAWA, O
    ECCLES, MR
    SZETO, J
    MCNOE, LA
    YUN, K
    MAW, MA
    SMITH, PJ
    REEVE, AE
    [J]. NATURE, 1993, 362 (6422) : 749 - 751
  • [76] Induction of WT1 (Wilms' tumor gene)-specific cytotoxic T lymphocytes by WT1 peptide vaccine and the resultant cancer regression
    Oka, Y
    Tsuboi, A
    Taguchi, T
    Osaki, T
    Kyo, T
    Nakajima, H
    Elisseeva, OA
    Oji, Y
    Kawakami, M
    Ikegame, K
    Hosen, N
    Yoshihara, S
    Wu, F
    Fujiki, F
    Murakami, M
    Masuda, T
    Nishida, S
    Shirakata, T
    Nakatsuka, S
    Sasaki, A
    Udaka, K
    Dohy, H
    Aozasa, K
    Noguchi, S
    Kawase, L
    Sugiyama, H
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (38) : 13885 - 13890
  • [77] Wnt/β-catenin signaling regulates nephron induction during mouse kidney development
    Park, Joo-Seop
    Valerius, M. Todd
    McMahon, Andrew P.
    [J]. DEVELOPMENT, 2007, 134 (13): : 2533 - 2539
  • [78] INACTIVATION OF WT1 IN NEPHROGENIC RESTS, GENETIC PRECURSORS TO WILMS-TUMOR
    PARK, S
    BERNARD, A
    BOVE, KE
    SENS, DA
    HAZENMARTIN, DJ
    GARVIN, AJ
    HABER, DA
    [J]. NATURE GENETICS, 1993, 5 (04) : 363 - 367
  • [79] Wilms' tumor 1 gene mutations independently predict poor outcome in adults with cytogenetically normal acute myeloid leukemia: A Cancer and Leukemia Group B study
    Paschka, Peter
    Marcucci, Guido
    Ruppert, Amy S.
    Whitman, Susan P.
    Mrozek, Krzysztof
    Maharry, Kati
    Langer, Christian
    Baldus, Claudia D.
    Zhao, Weiqiang
    Powell, Bayard L.
    Baer, Maria R.
    Carroll, Andrew J.
    Caligiuri, Michael A.
    Kolitz, Jonathan E.
    Larson, Richard A.
    Bloomfield, Clara D.
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (28) : 4595 - 4602
  • [80] GERMLINE MUTATIONS IN THE WILMS-TUMOR SUPPRESSOR GENE ARE ASSOCIATED WITH ABNORMAL UROGENITAL DEVELOPMENT IN DENYS-DRASH SYNDROME
    PELLETIER, J
    BRUENING, W
    KASHTAN, CE
    MAUER, SM
    MANIVEL, JC
    STRIEGEL, JE
    HOUGHTON, DC
    JUNIEN, C
    HABIB, R
    FOUSER, L
    FINE, RN
    SILVERMAN, BL
    HABER, DA
    HOUSMAN, D
    [J]. CELL, 1991, 67 (02) : 437 - 447
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