Wilms' tumours: about tumour suppressor genes, an oncogene and a chameleon gene

被引：190
作者：
Huff, Vicki [1 ,2 ,3 ]
机构：
[1] Univ Texas MD Anderson Canc Ctr, Dept Genet, Unit 1010, Houston, TX 77030 USA
[2] UT Houston Grad Sch Biomed Sci, Grad Program Genes & Dev, Houston, TX 77025 USA
[3] UT Houston Grad Sch Biomed Sci, Grad Program Human Mol Genet, Houston, TX 77025 USA
来源：
NATURE REVIEWS CANCER | 2011年 / 11卷 / 02期
关键词：
ACUTE MYELOID-LEUKEMIA; BECKWITH-WIEDEMANN-SYNDROME; HEMATOPOIETIC PROGENITOR CELLS; MINIMAL RESIDUAL DISEASE; EARLY KIDNEY DEVELOPMENT; WT1; MESSENGER-RNA; BETA-CATENIN; NEPHROGENIC RESTS; PROGNOSTIC-SIGNIFICANCE; WILMS-TUMOR-1; GENE;
D O I：
10.1038/nrc3002
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Genes identified as being mutated in Wilms' tumour include TP53, a classic tumour suppressor gene (TSG); CTNNB1 (encoding beta-catenin), a classic oncogene; WTX, which accumulating data indicate is a TSG; and WT1, which is inactivated in some Wilms' tumours, similar to a TSG. However, WT1 does not always conform to the TSG label, and some data indicate that WT1 enhances cell survival and proliferation, like an oncogene. Is WT1 a chameleon, functioning as either a TSG or an oncogene, depending on cellular context? Are these labels even appropriate for describing and understanding the function of WT1?
引用
收藏
页码：111 / 121
页数：11
相关论文
共 112 条
  • [101] Forced expression of the Wilms tumor 1 (WT1) gene inhibits proliferation of human hematopoietic CD34+ progenitor cells
    Svedberg, H
    Richter, J
    Gullberg, U
    [J]. LEUKEMIA, 2001, 15 (12) : 1914 - 1922
  • [102] Real-time quantitative PCR detection of WT1 gene expression in children with AML:: prognostic significance, correlation with disease status and residual disease detection by flow cytometry
    Trka, J
    Kalinová, M
    Hrusák, O
    Zuna, J
    Krejcí, O
    Madzo, J
    Sedlácek, P
    Vávra, V
    Michalová, K
    Jarosová, M
    Stary, J
    [J]. LEUKEMIA, 2002, 16 (07) : 1381 - 1389
  • [103] Constitutive expression of the Wilms' tumor gene WT1 inhibits the differentiation of myeloid progenitor cells but promotes their proliferation in response to granulocyte-colony stimulating factor (G-CSF)
    Tsuboi, A
    Oka, Y
    Ogawa, H
    Elisseeva, OA
    Tamaki, H
    Oji, Y
    Kim, EH
    Soma, T
    Tatekawa, T
    Kawakami, M
    Kishimoto, T
    Sugiyama, H
    [J]. LEUKEMIA RESEARCH, 1999, 23 (05) : 499 - 505
  • [104] Coordinating early kidney development: Lessons from gene targeting
    Vainio, S
    Lin, YF
    [J]. NATURE REVIEWS GENETICS, 2002, 3 (07) : 533 - 543
  • [105] Wilms tumor 1 (WT1) regulates KRAS-driven oncogenesis and senescence in mouse and human models
    Vicent, Silvestre
    Chen, Ron
    Sayles, Leanne C.
    Lin, Chenwei
    Walker, Randal G.
    Gillespie, Anna K.
    Subramanian, Aravind
    Hinkle, Gregory
    Yang, Xiaoping
    Saif, Sakina
    Root, David E.
    Huff, Vicki
    Hahn, William C.
    Sweet-Cordero, E. Alejandro
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2010, 120 (11) : 3940 - 3952
  • [106] Mutation of the Wilms' Tumor 1 Gene Is a Poor Prognostic Factor Associated With Chemotherapy Resistance in Normal Karyotype Acute Myeloid Leukemia: The United Kingdom Medical Research Council Adult Leukaemia Working Party
    Virappane, Priya
    Gale, Rosemary
    Hills, Robert
    Kakkas, Ioannis
    Summers, Karin
    Stevens, Jane
    Allen, Christopher
    Green, Claire
    Quentmeier, Hilmar
    Drexler, Hans
    Burnett, Alan
    Linch, David
    Bonnet, Dominique
    Lister, T. Andrew
    Fitzgibbon, Jude
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (33) : 5429 - 5435
  • [107] WTX Inactivation Is a Frequent, but Late Event in Wilms Tumors Without Apparent Clinical Impact
    Wegert, Jenny
    Wittmann, Stefanie
    Leuschner, Ivo
    Geissinger, Eva
    Graf, Norbert
    Gessler, Manfred
    [J]. GENES CHROMOSOMES & CANCER, 2009, 48 (12) : 1102 - 1111
  • [108] Beckwith-Wiedemann syndrome
    Weksberg, R
    Shuman, C
    Smith, AC
    [J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS, 2005, 137C (01) : 12 - 23
  • [109] TUMORS AND HEMIHYPERTROPHY ASSOCIATED WITH WIEDEMANN-BECKWITH SYNDROME
    WIEDEMANN, HR
    [J]. EUROPEAN JOURNAL OF PEDIATRICS, 1983, 141 (02) : 129 - 129
  • [110] Growth inhibition of human leukemic cells by WT1 (Wilms tumor gene) antisense oligodeoxynucleotides: Implications for the involvement of WT1 in leukemogenesis
    Yamagami, T
    Sugiyama, H
    Inoue, K
    Ogawa, H
    Tatekawa, T
    Hirata, M
    Kudoh, T
    Akiyama, T
    Murakami, A
    Maekawa, T
    Kishimoto, T
    [J]. BLOOD, 1996, 87 (07) : 2878 - 2884
3456789101112