Cumulative trauma, adversity and grief symptoms associated with fronto-temporal regions in life-course persistent delinquent boys

被引:11
作者
Lansing, Amy E. [1 ,3 ]
Virk, Agam [1 ]
Notestine, Randy [1 ]
Plante, Wendy Y. [1 ,3 ]
Fennema-Notestine, Christine [1 ,2 ]
机构
[1] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Dept Radiol, La Jolla, CA 92093 USA
[3] Univ Calif San Diego, Dept Sociol, La Jolla, CA 92093 USA
基金
美国国家卫生研究院;
关键词
Structural magnetic resonance imaging; Cumulative adversity; Complex trauma; Grief; Loss; Life-course persistent delinquent youth; Fronto-temporal regions; POSTTRAUMATIC-STRESS-DISORDER; GRAY-MATTER VOLUME; SURFACE-BASED ANALYSIS; ANTISOCIAL-BEHAVIOR; CHILDHOOD MALTREATMENT; CORTICAL THICKNESS; JUVENILE JUSTICE; COMMUNITY SAMPLE; BRAIN STRUCTURE; FRONTAL-CORTEX;
D O I
10.1016/j.pscychresns.2016.06.007
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Delinquent youth have substantial trauma exposure, with life-course persistent delinquents [LCPD] demonstrating notably elevated cross-diagnostic psychopathology and cognitive deficits. Because adolescents remain in the midst of brain and neurocognitive development, tailored interventions are key to improving functional outcomes. This structural magnetic resonance imaging study compared neuroanatomical profiles of 23 LCPD and 20 matched control adolescent boys. LCPD youth had smaller overall gray matter, and left hippocampal, volumes alongside less cortical surface area and folding within the left pars opercularis and supramarginal cortex. LCPD youth had more adversity-related exposures, and their higher Cumulative Trauma, Adversity and Grief [C-TAG] symptoms were associated with less surface area and folding in the pars opercularis and lingual gyrus. Neuroanatomical differences between LCPD and control youth overlap with data from both maltreatment and antisocial literatures. The affected left frontal regions also share connections to language- and executive-related functions, aligning well with LCPD youths' cognitive and behavioral difficulties. These data also dovetail with research suggesting the possibility of neurodevelopmental delays or disruptions related to cumulative adversity burden. Thus, concurrent treatment of LCPD youths' C-TAG symptoms and, cognitive deficits with overlapping neuroanatomical bases, may be most effective in improving outcomes and optimizing neurodevelopmental trajectories. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:92 / 102
页数:11
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