Ruthenium complexes as antimicrobial agents

被引:386
作者
Li, Fangfei [1 ]
Collins, J. Grant [1 ]
Keene, F. Richard [2 ,3 ,4 ]
机构
[1] Univ New S Wales, Australian Def Force Acad, Sch Phys Environm & Math Sci, Canberra, ACT 2600, Australia
[2] James Cook Univ, Ctr Biodiscovery & Mol Dev Therapeut, Townsville, Qld 4811, Australia
[3] James Cook Univ, Coll Sci Technol & Engn, Dept Matter & Mat, Townsville, Qld 4811, Australia
[4] Univ Adelaide, Sch Phys Sci, Dept Chem, Adelaide, SA 5005, Australia
关键词
DNA-BINDING; METAL-COMPLEXES; CELLULAR UPTAKE; ANTIBACTERIAL ACTION; ANTIBIOTICS; MECHANISM; AFFINITY; TARGET; PROBE; ACID;
D O I
10.1039/c4cs00343h
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
One of the major advances in medical science has been the development of antimicrobials; however, a consequence of their widespread use has been the emergence of drug-resistant populations of microorganisms. There is clearly a need for the development of new antimicrobials - but more importantly, there is the need for the development of new classes of antimicrobials, rather than drugs based upon analogues of known scaffolds. Due to the success of the platinum anticancer agents, there has been considerable interest in the development of therapeutic agents based upon other transition metals - and in particular ruthenium(II/III) complexes, due to their well known interaction with DNA. There have been many studies of the anticancer properties and cellular localisation of a range of ruthenium complexes in eukaryotic cells over the last decade. However, only very recently has there been significant interest in their antimicrobial properties. This review highlights the types of ruthenium complexes that have exhibited significant antimicrobial activity and discusses the relationship between chemical structure and biological processing - including site(s) of intracellular accumulation - of the ruthenium complexes in both bacterial and eukaryotic cells.
引用
收藏
页码:2529 / 2542
页数:14
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