Molecular Mechanisms of 5-Fluorocytosine Resistance in Yeasts and Filamentous Fungi

被引：46

作者：

Delma, Fatima Zohra ^{[1
]}

Al-Hatmi, Abdullah M. S. ^{[2
,3
,4
]}

Bruggemann, Roger J. M. ^{[3
,5
]}

Melchers, Willem J. G. ^{[1
,3
]}

de Hoog, Sybren ^{[3
,4
]}

Verweij, Paul E. ^{[1
,3
]}

Buil, Jochem B. ^{[1
,3
]}

机构：

[1] Radboud Univ Nijmegen Med Ctr, Dept Med MicroBiol, NL-6252 AG Nijmegen, Netherlands

[2] Univ Nizwa, Nat & Med Sci Res Ctr, Nizwa 616, Oman

[3] Radboudumc Ctr Infect Dis RCI, Ctr Expertise Mycol Radboudumc CWZ, NL-6252 AG Nijmegen, Netherlands

[4] Fdn Atlas Clin Fungi, NL-1214 GP Hilversum, Netherlands

[5] Radboud Univ Nijmegen Med Ctr, Dept Pharm, NL-6252 AG Nijmegen, Netherlands

来源：

JOURNAL OF FUNGI | 2021年 / 7卷 / 11期

关键词：

5-fluorocytosine; resistance; molecular mechanisms; INFECTIOUS-DISEASES SOCIETY; IN-VITRO ACTIVITIES; FLUCONAZOLE CROSS-RESISTANCE; FLUCYTOSINE RESISTANCE; AMPHOTERICIN-B; CANDIDA-ALBICANS; CRYPTOCOCCUS-GATTII; PRACTICE GUIDELINES; ANTIFUNGAL AGENTS; 2016; UPDATE;

D O I：

10.3390/jof7110909

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Effective management and treatment of fungal diseases is hampered by poor diagnosis, limited options for antifungal therapy, and the emergence of antifungal drug resistance. An understanding of molecular mechanisms contributing to resistance is essential to optimize the efficacy of currently available antifungals. In this perspective, one of the oldest antifungals, 5-fluorocytosine (5-FC), has been the focus of recent studies applying advanced genomic and transcriptomic techniques to decipher the order of events at the molecular level that lead to resistance. These studies have highlighted the complexity of resistance and provided new insights that are reviewed in the present paper.

引用

页数：14

共 81 条

[1] Genotypic heterogeneity and molecular basis of 5-flucytosine resistance among Candida dubliniensis isolates recovered from clinical specimens in Kuwait [J].

Ahmad, Suhail ;

Khan, Zia U. ;

Joseph, Leena ;

Asadzadeh, Mohammad ;

Theyyathel, Ajmal .

MEDICAL MYCOLOGY, 2012, 50 (03) :244-251

[2] Novel 5-flucytosine-resistant clade of Candida dubliniensis from Saudi Arabia and Egypt identified by Cd25 fingerprinting [J].

Al Mosaid, A ;

Sullivan, DJ ;

Polacheck, I ;

Shaheen, FA ;

Soliman, O ;

Al Hedaithy, S ;

Al Thawad, S ;

Kabadaya, M ;

Coleman, DC .

JOURNAL OF CLINICAL MICROBIOLOGY, 2005, 43 (08) :4026-4036

[3] STUDY OF 666 STRAINS OF CANDIDA-ALBICANS - CORRELATION BETWEEN SEROTYPE AND SUSCEPTIBILITY TO 5-FLUOROCYTOSINE [J].

AUGER, P ;

DUMAS, C ;

JOLY, J .

JOURNAL OF INFECTIOUS DISEASES, 1979, 139 (05) :590-594

[4] Primary resistance to flucytosine among clinical isolates of Candida spp. [J].

Barchiesi, F ;

Arzeni, D ;

Caselli, F ;

Scalise, G .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2000, 45 (03) :408-409

[5] COMPARISON OF AMPHOTERICIN-B ALONE AND COMBINED WITH FLUCYTOSINE IN THE TREATMENT OF CRYPTOCCAL MENINGITIS [J].

BENNETT, JE ;

DISMUKES, WE ;

DUMA, RJ ;

MEDOFF, G ;

SANDE, MA ;

GALLIS, H ;

LEONARD, J ;

FIELDS, BT ;

BRADSHAW, M ;

HAYWOOD, H ;

MCGEE, ZA ;

CATE, TR ;

COBBS, CG ;

WARNER, JF ;

ALLING, DW .

NEW ENGLAND JOURNAL OF MEDICINE, 1979, 301 (03) :126-131

[6] Gene Duplication Associated with Increased Fluconazole Tolerance in Candida auris cells of Advanced Generational Age [J].

Bhattacharya, Somanon ;

Holowka, Thomas ;

Orner, Erika P. ;

Fries, Bettina C. .

SCIENTIFIC REPORTS, 2019, 9 (1)

[7] 5-fluorocytosine resistance is associated with hypermutation and alterations in capsule biosynthesis in Cryptococcus [J].

Billmyre, R. Blake ;

Clancey, Shelly Applen ;

Li, Lucy X. ;

Doering, Tamara L. ;

Heitman, Joseph .

NATURE COMMUNICATIONS, 2020, 11 (01)

[8] Multiplex Genetic Engineering Exploiting Pyrimidine Salvage Pathway-Based Endogenous Counterselectable Markers [J].

Birstonas, Lukas ;

Dallemulle, Alex ;

Lopez-Berges, Manuel S. ;

Jacobsen, Ilse D. ;

Offterdinger, Martin ;

Abt, Beate ;

Strassburger, Maria ;

Bauer, Ingo ;

Schmidt, Oliver ;

Sarg, Bettina ;

Lindner, Herbert ;

Haas, Hubertus ;

Gsaller, Fabio .

MBIO, 2020, 11 (02)

[9] 5-FLUOROCYTOSINE RESISTANCE IN CRYPTOCOCCUS-NEOFORMANS [J].

BLOCK, ER ;

JENNINGS, AE ;

BENNETT, JE .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1973, 3 (06) :649-656

[10] PHARMACOLOGICAL STUDIES WITH 5-FLUOROCYTOSINE [J].

BLOCK, ER ;

BENNETT, JE .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1972, 1 (06) :476-&

← 1 2 3 4 5 6 7 8 9 →