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Sarco(endo)plasmic reticulum calcium pumps: recent advances in our understanding of structure/function and biology (Review)
被引：78
|作者：
East, JM
[1
]
机构：
[1] Univ Southampton, Sch Biol Sci, Div Biochem & Mol Biol, Southampton SO16 7PX, Hants, England
关键词：
calcium pumps;
x-ray structure;
genetic diseases;
phospholamban;
sarcolipin;
D O I：
10.1080/09687680010009646
中图分类号：
Q5 [生物化学];
Q7 [分子生物学];
学科分类号：
071010 ;
081704 ;
摘要：
This review examines the structure and function of the sarco(endo)plasmic reticulum calcium pump (SERCA1a) in the light of the recent publication of the 2.6 Angstrom resolution structure of this protein, and looks at the increasing awareness of the key role played by SERCAs in calcium signalling. The roles played by the calcium pump isoforms, SERCA1a/b, SERCA2a/b and SERCA3a/b/c in cellular function are discussed, and the modulation of SERCA activity by phospholamban, sarcolipin and other modulatory influences is examined. The recent discoveries of human SERCA mutations leading to disease states is reviewed, and the Insights into SERCA function using transgenic approaches are outlined.
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页码：189 / 200
页数：12
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