Hormozgan province has generally calcareous soils and so it has deficits of microelements. Therefore, method and suitable rate of using these elements need to be designed in agriculture. For this object, the effects of different amounts of zinc and iron and their interaction effects on quantitative and qualitative yield of wheat (Triticum durum L.) in this area were studied. An experiment was conducted in completely randomized design with three replications. The treatments were in four levels of Fe (0, 5, 10 and 15 kg/ha of Fe from 138 secostron) and in four levels of Zn include 0, 25,50 and 75 kg/ha of Zn element from zinc sulfate. The results showed that the effect of different levels of Fe and Zn on straw and grain yield, cluster numbers in area unit, weight of 1000 grains, number of grains in spike, amount of protein and amount of Fe and Zn in grain had significant difference at the 1% level. So, the amount of Fe application caused decreasing of Zn in grains and diversely the amount of Zn application caused decreasing of Fe in grain but these effects were not significant. Interactions of Fe and Zn were positive and their effect on studied parameters had significant difference at the 1% level. Highest grain yield was related to Zn75Fe10 treatment that was 5728 kg/ha.