A chemoenzymatic, enantioconvergent, asymmetric total synthesis of (R)-Fridamycin E

被引：24

作者：

Ueberbacher, BJ ^{[1
]}

Osprian, I ^{[1
]}

Mayer, SF ^{[1
]}

Faber, K ^{[1
]}

机构：

[1] Graz Univ, Dept Chem Organ & Bioorgan Chem, A-8010 Graz, Austria

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 2005卷 / 07期

关键词：

asymmetric synthesis; biotransformations; enzyme catalysis; natural products; total synthesis;

D O I：

10.1002/ejoc.200400720

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A chemoenzymatic, asymmetric total synthesis of the antibiotic (R)-fridamycin E has been accomplished following a biocatalytic deracemization procotol. The key step comprises the construction of the chiral side-chain from a functionalized rac-2,2-disubstituted oxirane via a kinetic resolution/stereo-inversion sequence without formation of the undesiredstereoisomer.

引用

页码：1266 / 1270

页数：5

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