Myc transcription factors: key regulators behind establishment and maintenance of pluripotency

被引：16
作者：
Smith, Keriayn [1 ,2 ]
Dalton, Stephen [1 ]
机构：
[1] Univ Georgia, Dept Biochem & Mol Biol, Paul D Coverdell Ctr Biomed & Hlth Sci, Athens, GA 30602 USA
[2] Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USA
来源：
REGENERATIVE MEDICINE | 2010年 / 5卷 / 06期
关键词：
embryonic stem cell; induced pluripotent stem cell; Myc; pluripotent reprogramming; self-renewal; EMBRYONIC STEM-CELLS; C-MYC; N-MYC; SELF-RENEWAL; DEVELOPMENTAL REGULATORS; HUMAN FIBROBLASTS; MOUSE EMBRYOS; HUMAN GENOME; DNA-BINDING; GENERATION;
D O I：
10.2217/RME.10.79
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
The interplay between transcription factors, epigenetic modifiers, chromatin remodelers and miRNAs form the foundation of a complex regulatory network required for establishment and maintenance of the pluripotent state. Recent work indicates that Myc transcription factors are essential elements of this regulatory system. However, despite numerous studies, aspects of how Myc controls self-renewal and pluripotency remain obscure. This article reviews evidence supporting the placement of Myc as a central regulator of the pluripotent state and discusses possible mechanisms of action.
引用
收藏
页码：947 / 959
页数：13
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