Vitamin D, Calcidiol and Calcitriol Regulate Vitamin D Metabolizing Enzymes in Cervical and Ovarian Cancer Cells

被引：1

作者：

Kloss, Martin ^{[1
]}

Fischer, Dorothea ^{[1
]}

Thill, Marc ^{[1
]}

Friedrich, Michael ^{[2
]}

Cordes, Tim ^{[1
]}

Salehin, Darius ^{[2
]}

Diedrich, Klaus ^{[1
]}

Koester, Frank ^{[1
]}

机构：

[1] Med Univ Lubeck, Dept Obstet & Gynecol, D-23538 Lubeck, Germany

[2] HELIOS Hosp Krefeld, Dept Obstet & Gynecol, D-47805 Krefeld, Germany

来源：

ANTICANCER RESEARCH | 2010年 / 30卷 / 11期

关键词：

Cervical cancer; ovarian cancer; 25-hydroxylase; 1; alpha-hydroxylase; 24-hydroxylase; vitamin D; calcidiol; calcitriol; PROSTATIC EPITHELIAL-CELLS; MALIGNANT BREAST-TISSUE; 1,25-DIHYDROXYVITAMIN D-3; 25-HYDROXYVITAMIN D-3; D-RECEPTOR; 1-ALPHA; 25-DIHYDROXYVITAMIN D-3; 24-HYDROXYLASE ACTIVITY; CARCINOMA-CELLS; GROWTH; LINES;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: The vitamin D metabolizing enzymes 25-, 1 alpha- and 24-hydroxylase are expressed in malignant cells of the cervix and the ovaries. The aim of this study was to obtain further information about the regulation of the aforementioned enzymes by vitamin D, calcidiol and calcitriol in cervical and ovarian cancer. Materials and Methods: The human cervical adenocarcinoma cell line HeLa and the human ovarian adenocarcinoma cell line OVCAR-3 were incubated with vitamin D, calcidiol and calcitriol. The influence of vitamin D and its metabolites on the expression of 25-, 1 alpha- and 24-hydroxylase was assessed by real-time RTPCR. Results: Calcitriol significantly increased the 24-hydroxylase mRNA levels in HeLa and OVCAR-3 cells. The expression of 25- and 1 alpha-hydroxylase was not regulated in a statistically significant manner. Conclusion: These results suggest that in HeLa as well as OVCAR-3 cell lines, the metabolism of vitamin D is regulated via the expression of the catabolizing 24-hydroxylase.

引用

页码：4429 / 4434

页数：6

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