Lipidomics in the study of lipid metabolism: Current perspectives in the omic sciences

被引：65

作者：

Holanda Rolim, Ana Emilia ^{[1
]}

Henrique-Araujo, Ricardo ^{[1
]}

Ferraz, Eduardo Gomes ^{[1
]}

de Araujo Alves Dultra, Fatima Karoline ^{[1
]}

Fernandez, Luzimar Gonzaga ^{[2
]}

机构：

[1] Univ Fed Bahia, Inst Hlth Sci, Postgrad Program Interact Proc Organs & Syst, BR-40160100 Salvador, BA, Brazil

[2] Fed Univ Bahia UFBA, Inst Hlth Sci ICS, Lab Biochem Biotechnol & Bioprod, Dept Biofuncao, BR-40160100 Salvador, BA, Brazil

来源：

GENE | 2015年 / 554卷 / 02期

关键词：

Metabolomics; Lipids; Pharmacolipidomics; MASS-SPECTROMETRY; PROTEIN INTERACTIONS; SHOTGUN LIPIDOMICS; CRUDE EXTRACTS; POTENTIAL ROLE; HUMAN BLOOD; METABOLOMICS; PLASMA; CHROMATOGRAPHY; SPHINGOLIPIDS;

D O I：

10.1016/j.gene.2014.10.039

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The advances in systems biology and in the development of new technological tools in analysis, as well as in the omic sciences, among which, metabolomics, and more specifically, lipidomics, have made it possible to investigate the structural and functional complexity of lipids in biological systems. Liquid chromatography and mass spectrometry are the analytical approaches most used in lipid research. Biomedical research, with the development of specific markers for lipids, together with new software development, have both enabled the early diagnosis of several illnesses, besides the evaluation of drug activity and treatment efficacy. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：131 / 139

页数：9

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