Targeting Protein-Protein Interactions: A Promising Avenue of Anti-HIV Drug Discovery

被引:17
作者
Zhan, Peng [1 ]
Li, Wenjun [1 ]
Chen, Hongfei [1 ]
Liu, Xinyong [1 ]
机构
[1] Shandong Univ, Dept Med Chem, Sch Pharmaceut Sci, Jinan 250012, Shandong, Peoples R China
基金
高等学校博士学科点专项科研基金; 中国国家自然科学基金;
关键词
HIV; AIDS; drug design; drug targets; protein-protein interactions; inhibitor; HUMAN-IMMUNODEFICIENCY-VIRUS; SMALL-MOLECULE INHIBITORS; REVERSE-TRANSCRIPTASE DIMERIZATION; CYCLOSPORINE-A ANALOG; TSAO DERIVATIVES; NUCLEAR IMPORT; CYCLOPHILIN-A; BINDING-SITE; CONFORMATIONAL-CHANGES; CELLULAR COFACTORS;
D O I
10.2174/092986710793176357
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In recent years, the number of useful chemical biology information of protein-protein interactions in the HIV life cycle and related inhibitors, is growing rapidly, which makes protein-protein interactions a new investigative area for antiviral drug intervention. This review will summarize recent work in this field, mainly focusing on the utilization of small molecules targeted against a variety of protein-protein interactions that have great therapeutic feasibility for HIV infection, and lastly outline some other important protein-protein interactions with a potential to advance into novel anti-HIV drug targets in future.
引用
收藏
页码:3393 / 3409
页数:17
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