Targeting Protein-Protein Interactions: A Promising Avenue of Anti-HIV Drug Discovery

被引：17

作者：

Zhan, Peng ^{[1
]}

Li, Wenjun ^{[1
]}

Chen, Hongfei ^{[1
]}

Liu, Xinyong ^{[1
]}

机构：

[1] Shandong Univ, Dept Med Chem, Sch Pharmaceut Sci, Jinan 250012, Shandong, Peoples R China

来源：

CURRENT MEDICINAL CHEMISTRY | 2010年 / 17卷 / 29期

基金：

高等学校博士学科点专项科研基金; 中国国家自然科学基金;

关键词：

HIV; AIDS; drug design; drug targets; protein-protein interactions; inhibitor; HUMAN-IMMUNODEFICIENCY-VIRUS; SMALL-MOLECULE INHIBITORS; REVERSE-TRANSCRIPTASE DIMERIZATION; CYCLOSPORINE-A ANALOG; TSAO DERIVATIVES; NUCLEAR IMPORT; CYCLOPHILIN-A; BINDING-SITE; CONFORMATIONAL-CHANGES; CELLULAR COFACTORS;

D O I：

10.2174/092986710793176357

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In recent years, the number of useful chemical biology information of protein-protein interactions in the HIV life cycle and related inhibitors, is growing rapidly, which makes protein-protein interactions a new investigative area for antiviral drug intervention. This review will summarize recent work in this field, mainly focusing on the utilization of small molecules targeted against a variety of protein-protein interactions that have great therapeutic feasibility for HIV infection, and lastly outline some other important protein-protein interactions with a potential to advance into novel anti-HIV drug targets in future.

引用

页码：3393 / 3409

页数：17

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