Targeting Protein-Protein Interactions: A Promising Avenue of Anti-HIV Drug Discovery

被引：17

作者：

Zhan, Peng ^{[1
]}

Li, Wenjun ^{[1
]}

Chen, Hongfei ^{[1
]}

Liu, Xinyong ^{[1
]}

机构：

[1] Shandong Univ, Dept Med Chem, Sch Pharmaceut Sci, Jinan 250012, Shandong, Peoples R China

来源：

CURRENT MEDICINAL CHEMISTRY | 2010年 / 17卷 / 29期

基金：

高等学校博士学科点专项科研基金; 中国国家自然科学基金;

关键词：

HIV; AIDS; drug design; drug targets; protein-protein interactions; inhibitor; HUMAN-IMMUNODEFICIENCY-VIRUS; SMALL-MOLECULE INHIBITORS; REVERSE-TRANSCRIPTASE DIMERIZATION; CYCLOSPORINE-A ANALOG; TSAO DERIVATIVES; NUCLEAR IMPORT; CYCLOPHILIN-A; BINDING-SITE; CONFORMATIONAL-CHANGES; CELLULAR COFACTORS;

D O I：

10.2174/092986710793176357

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In recent years, the number of useful chemical biology information of protein-protein interactions in the HIV life cycle and related inhibitors, is growing rapidly, which makes protein-protein interactions a new investigative area for antiviral drug intervention. This review will summarize recent work in this field, mainly focusing on the utilization of small molecules targeted against a variety of protein-protein interactions that have great therapeutic feasibility for HIV infection, and lastly outline some other important protein-protein interactions with a potential to advance into novel anti-HIV drug targets in future.

引用

页码：3393 / 3409

页数：17

共 50 条

[1] Targeting Protein-Protein and Protein-Nucleic Acid Interactions for Anti-HIV Therapy
Mori, Mattia
Manetti, Fabrizio
Botta, Maurizio
CURRENT PHARMACEUTICAL DESIGN, 2011, 17 (33) : 3713 - 3728
[2] Protein-protein interactions in bacteria: a promising and challenging avenue towards the discovery of new antibiotics
Carro, Laura
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, 2018, 14 : 2881 - 2896
[3] Targeting Protein-Protein Interactions and Fragment-Based Drug Discovery
Valkov, Eugene
Sharpe, Tim
Marsh, May
Greive, Sandra
Hyvoenen, Marko
FRAGMENT-BASED DRUG DISCOVERY AND X-RAY CRYSTALLOGRAPHY, 2012, 317 : 145 - 179
[4] Drug discovery by targeting the protein-protein interactions involved in autophagy
Xiang, Honggang
Zhou, Mi
Li, Yan
Zhou, Lu
Wang, Renxiao
ACTA PHARMACEUTICA SINICA B, 2023, 13 (11) : 4373 - 4390
[5] Inhibiting Protein-Protein Interactions as an Emerging Paradigm for Drug Discovery
Gerrard, J. A.
Hutton, C. A.
Perugini, M. A.
MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2007, 7 (02) : 151 - 157
[6] Computer-aided design and discovery of protein-protein interaction inhibitors as agents for anti-HIV therapy
Veselovsky, A. V.
Zharkova, M. S.
Poroikov, V. V.
Nicklaus, M. C.
SAR AND QSAR IN ENVIRONMENTAL RESEARCH, 2014, 25 (06) : 457 - 471
[7] Hot-spot analysis for drug discovery targeting protein-protein interactions
Rosell, Mireia
Fernandez-Recio, Juan
EXPERT OPINION ON DRUG DISCOVERY, 2018, 13 (04) : 327 - 338
[8] Databases of protein-protein interactions and their use in drug discovery
Fuentes, Gloria
Oyarzabal, Julen
Rojas, Ana M.
CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT, 2009, 12 (03) : 358 - 366
[9] Computational Drug Design Targeting Protein-Protein Interactions
Bienstock, Rachelle J.
CURRENT PHARMACEUTICAL DESIGN, 2012, 18 (09) : 1240 - 1254
[10] Targeting the protein-protein interactions of the HIV lifecycle
Tavassoli, Ali
CHEMICAL SOCIETY REVIEWS, 2011, 40 (03) : 1337 - 1346

← 1 2 3 4 5 →