The Metabolic Intermediate Alpha-Ketoglutarate Suppresses the TGFβ-driven Profibrotic Responses of Dermal Fibroblasts

被引：0

作者：

Burja, Blaz ^{[1
]}

Kania, Gabriela ^{[1
]}

Tomsic, Matija ^{[2
]}

Janko, Tea ^{[2
]}

Sodin-Semrl, Snezna ^{[2
]}

Distler, Oliver ^{[3
]}

Lakota, Katja ^{[2
]}

Frank-Bertoncelj, Mojca ^{[4
]}

机构：

[1] Univ Hosp Zurich, Dept Rheumatol, Ctr Expt Rheumatol, Zurich, Switzerland

[2] Univ Med Ctr Ljubljana, Dept Rheumatol, Ljubljana, Slovenia

[3] Univ Hosp Zurich, Dept Rheumatol, Zurich, Switzerland

[4] Univ Hosp Zurich, Zurich, Switzerland

来源：

ARTHRITIS & RHEUMATOLOGY | 2019年 / 71卷

关键词：

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

1043

引用

页数：3

共 50 条

[31] Protein tyrosine phosphatase-alpha (PTPα) promotes profibrotic responses in lung fibroblasts [J].

Downey, Gregory P. ;

Aschner, Yael .

EUROPEAN RESPIRATORY JOURNAL, 2017, 50

[32] Protein Tyrosine Phosphatase-Alpha (ptpa) Promotes Profibrotic Responses In Lung Fibroblasts [J].

Aschner, Y. ;

Nelson, M. R. ;

Wong, M. I. ;

Nicholson, Y. T. ;

McClendon, J. ;

Jansing, N. ;

Zemans, R. L. ;

Downey, G. P. .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2017, 195

[33] Alpha-ketoglutarate stimulates procollagen production in cultured human dermal fibroblasts, and decreases UVB-induced wrinkle formation following topical application on the dorsal skin of hairless mice [J].

Son, Eui Dong ;

Choi, Gyu Ho ;

Kim, Hyaekyoung ;

Lee, Byoungseok ;

Chang, Ih Seoup ;

Sun-Hwang, Jae .

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2007, 30 (08) :1395-1399

[34] Alpha-ketoglutarate stimulates collagen production in cultured human dermal fibroblasts, and decreases UVB-induced wrinkle formation following topical application on the dorsal skin of hairless mice [J].

Son, E. ;

Kim, H. ;

Choi, H. ;

Chang, I. ;

Hwang, J. .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2007, 127 :S37-S37

[35] Alpha-ketoglutarate promotes anxiety, activates autophagy, and suppresses antioxidant enzymes in the cerebral cortex of female mice on cafeteria diet [J].

Demianchuk, Oleh ;

Bayliak, Maria ;

Vatashchuk, Myroslava ;

Gospodaryov, Dmytro ;

Hurza, Viktoriia ;

Derkachov, Vitalii ;

Berezovskyi, Vladyslav ;

Lushchak, Volodymyr I. .

BRAIN RESEARCH BULLETIN, 2025, 222

[36] Metabolic remodeling results in alterations in the redox responses of human dermal fibroblasts [J].

Pinho, Sonia A. ;

Costa, Claudio ;

Miranda-Santos, Ines ;

Pinho, Sonia L. ;

Oliveira, Paulo J. ;

Cunha-Oliveira, Teresa .

FREE RADICAL BIOLOGY AND MEDICINE, 2021, 165

[37] Cartilage Intermediate Layer Protein 1 Suppresses TGF-β Signaling in Cardiac Fibroblasts [J].

Shindo, Kazuhiro ;

Asakura, Masanori ;

Min, Kyung-Duk ;

Ito, Shin ;

Fu, Hai Ying ;

Yamazaki, Satoru ;

Takahashi, Ayako ;

Imazu, Miki ;

Fukuda, Hiroki ;

Nakajima, Yuri ;

Asanuma, Hiroshi ;

Minamino, Tetsuo ;

Takashima, Seiji ;

Minamino, Naoto ;

Mochizuki, Naoki ;

Kitakaze, Masafumi .

INTERNATIONAL JOURNAL OF GERONTOLOGY, 2017, 11 (02) :67-74

[38] FUNCTIONAL AND METABOLIC CHANGES IN INTESTINAL-MUCOSA OF RATS AFTER ENTERAL ADMINISTRATION OF ORNITHINE ALPHA-KETOGLUTARATE SALT [J].

RAUL, F ;

GOSSE, F ;

GALLUSER, M ;

HASSELMANN, M ;

SEILER, N .

JOURNAL OF PARENTERAL AND ENTERAL NUTRITION, 1995, 19 (02) :145-150

[39] Transcriptional and Metabolic Profiling Reveals Alpha-Ketoglutarate As a Novel Mediator of Aberrant Platelet Activity and Inflammation in Myeloproliferative Neoplasms [J].

He, Fan ;

Laranjeira, Angelo Ba ;

Kong, Tim ;

Bark, Katrina ;

Liu, Alice ;

Allen, Maggie J. ;

Fisher, Daniel Ac ;

Fulbright, Mary ;

Yu, LaYow ;

Lasky, Nina M. ;

Sykes, Stephen M. ;

D'Alessandro, Angelo ;

Di Paola, Jorge ;

Oh, Stephen T. .

BLOOD, 2022, 140 :1095-1097

[40] PTP-Alpha Promotes TGF-Beta Profibrotic Responses Via Activation of Src [J].

Aschner, Y. ;

Nelson, M. R. ;

Wong, M. I. ;

Roybal, H. ;

Holly, R. ;

Downey, G. P. .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2018, 197

← 1 2 3 4 5 →