Analysis of 6q deletion in Waldenstrom macroglobulinemia

被引：18

作者：

Chang, Hong ^{[1
]}

Qi, Xiaoying

Xu, Wei

Reader, Jocelyn C.

Ning, Yi

机构：

[1] Univ Toronto, Univ Hlth Network, Dept Lab Med & Pathobiol, Dept Lab Hematol, Toronto, ON, Canada

[2] Univ Maryland, Dept Pathol, Baltimore, MD 21201 USA

来源：

EUROPEAN JOURNAL OF HAEMATOLOGY | 2007年 / 79卷 / 03期

关键词：

Waldenstrom macroglobulinemia; 6q deletions; FISH;

D O I：

10.1111/j.1600-0609.2007.00903.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The frequency and prognostic significance of chromosome 6q deletion were investigated in a cohort of patients with Waldenstrom macroglobulinemia (WM). By interphase cytoplasmic fluorescence in situ hybridization with probes for 6q21 and 6q25, we detected hemizygous 6q deletions in the clonal lymphoplasmacytic cells in 13 (38%) out of 34 patients. Patients with 6q deletions had a lower IgM paraprotein levels than non-deleted patients (P = 0.04). There was no correlation between 6q deletion and other clinical features of WM. There was no significant difference in overall survival between 6q deleted and non-6q deleted groups (P = 0.92). Our study confirms that 6q deletion is a frequent event, but it does not appear to be a prognostic marker for patients with WM.

引用

页码：244 / 247

页数：4

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