Coronary Artery Bypass Surgery Provokes Alzheimer's Disease-Like Changes in the Cerebrospinal Fluid

被引：77

作者：

Palotas, Andras ^{[1
]}

Reis, Helton J. ^{[2
]}

Bogats, Gabor ^{[3
]}

Babik, Barna ^{[3
,4
]}

Racsmany, Mihaly ^{[5
,6
]}

Engvau, Linda ^{[6
,7
]}

Kecskemeti, Eva ^{[6
,7
]}

Juhasz, Anna ^{[7
]}

Vieira, Luciene B. ^{[2
]}

Teixeira, Antonio L. ^{[8
]}

Mukhamedyarov, Marat A. ^{[9
]}

Rizvanov, Albert A. ^{[10
,11
,12
]}

Yalvac, Mehmet E. ^{[12
]}

Guimaraes, Melissa M. ^{[2
,13
]}

Ferreira, Claudia N. ^{[14
]}

Zefirov, Andrey L. ^{[9
]}

Kiyasov, Andrey P. ^{[15
]}

Wang, Lan ^{[16
]}

Janka, Zoltan ^{[7
]}

Kalman, Janos ^{[7
]}

机构：

[1] Asklepios Med, H-6722 Szeged, Hungary

[2] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Farmacol, Lab Neurofarmacol, Belo Horizonte, MG, Brazil

[3] Univ Szeged, Fac Med, Ctr Cardiol, Div Cardiac Surg,Albert Szent Gyorgyi Clin Ctr, Szeged, Hungary

[4] Univ Szeged, Fac Med, Dept Anesthesiol & Intens Therapy, Albert Szent Gyorgyi Clin Ctr, Szeged, Hungary

[5] Budapest Univ Technol & Econ, Dept Cognit Sci, H-1117 Budapest, Hungary

[6] Univ Szeged, Dept Psychol, Szeged, Hungary

[7] Univ Szeged, Fac Med, Dept Psychiat, Albert Szent Gyorgyi Clin Ctr, Szeged, Hungary

[8] Univ Fed Minas Gerais, Fac Med, Dept Clin Med, Belo Horizonte, MG, Brazil

[9] Kazan State Med Univ, Dept Physiol, Kazan, Russia

[10] Kazan VI Lenin State Univ, Fac Biol & Soil Sci, Dept Genet, Kazan 420008, Russia

[11] Kazan State Med Univ, Core Res Lab, Kazan, Russia

[12] Yeditepe Univ, Coll Engn & Architecture, Dept Genet & BioEngn, Istanbul, Turkey

[13] Univ Fed Vales Jequitinhonha & Mucuri, Fac Ciencias Saude, Dept Ciencias Basicas, Ctr Diamantina, Belo Horizonte, MG, Brazil

[14] Univ Fed Minas Gerais, Fac Farm, Dept Anal Clin & Toxicol, Belo Horizonte, MG, Brazil

[15] Kazan State Med Univ, Dept Anat, Kazan, Russia

[16] Univ Cambridge, Inst Biotechnol, Cambridge Ctr Neuropsychiat Res, Cambridge, England

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2010年 / 21卷 / 04期

基金：

匈牙利科学研究基金会; 俄罗斯基础研究基金会;

关键词：

Alzheimer's disease; amyloid-beta peptide; biomarker; cardiac surgery; cerebrospinal fluid; cognitive function; postoperative cognitive decline; S100; beta; tau; AMYLOID PRECURSOR PROTEIN; CARDIOPULMONARY BYPASS; MESSENGER-RNA; BETA-PROTEIN; DENSITY-LIPOPROTEIN; OFF-PUMP; BRAIN; TAU; ASSOCIATION; ACTIVATION;

D O I：

10.3233/JAD-2010-100702

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Several biomarkers are used in confirming the diagnosis of cognitive disorders. This study evaluates whether the level of these markers after heart surgery correlates with the development of cognitive dysfunction, which is a frequent complication of cardiac interventions. Concentrations of amyloid-beta peptide, tau, and S100 beta in the cerebro-spinal fluid were assessed, as well as cognitive functions were evaluated before and after coronary artery bypass grafting, utilizing immuno-assays and psychometric tests, respectively. A drastic rise in the level of S100 beta was observed one week after the surgery, a mark of a severe generalized cerebral injury. The level of amyloid-beta peptide significantly decreased, whereas the concentration of tau markedly increased six months postoperatively. Gradual cognitive decline was also present. These findings clearly demonstrate post-surgical cognitive impairment associated with changes in biomarkers similar to that seen in Alzheimer's disease, suggesting a unifying pathognomic factor between the two disorders. A holistic approach to coronary heart disease and Alzheimer's-type dementia is proposed.

引用

页码：1153 / 1164

页数：12

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