Importance of the Caspase Cleavage Site in Amyloid-β Protein Precursor

被引：22

作者：

Bredesen, Dale E. ^{[1
,2
]}

John, Varghese ^{[1
]}

Galvan, Veronica ^{[3
,4
]}

机构：

[1] Buck Inst Age Res, Novato, CA 94945 USA

[2] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA

[3] Univ Texas Hlth Sci Ctr San Antonio, Dept Physiol, San Antonio, TX 78284 USA

[4] Univ Texas Hlth Sci Ctr San Antonio, Sam & Ann Barshop Inst Longev & Aging Studies, San Antonio, TX USA

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2010年 / 22卷 / 01期

关键词：

Alzheimer's disease; amyloid-beta peptide caspases; transgenic mouse; C-TERMINAL CLEAVAGE; ALZHEIMERS-DISEASE; TRANSGENIC MICE; POLYGLUTAMINE TRACT; HUNTINGTON-DISEASE; MUTANT HUNTINGTIN; MOUSE MODELS; APOPTOSIS; EXPRESSION; RECEPTOR;

D O I：

10.3233/JAD-2010-100537

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Reports from multiple laboratories have now been published analyzing the critical nature of the caspase cleavage site of amyloid-beta protein precursor (A beta PP) for cell death induction, synaptic loss, hippocampal atrophy, long-term potentiation, memory loss, neophobia, and other aspects of the Alzheimer's phenotype. Here we review the results and implications of these studies for the understanding of Alzheimer's disease pathophysiology and the potential development of therapeutics that target this site in A beta PP.

引用

页码：57 / 63

页数：7

共 51 条

[1] Activation of caspase-6 in aging and mild cognitive impairment [J].

Albrecht, Steffen ;

Bourdeau, Martine ;

Bennett, David ;

Mufson, Elliott J. ;

Bhattacharjee, Meena ;

LeBlanc, Andrea C. .

AMERICAN JOURNAL OF PATHOLOGY, 2007, 170 (04) :1200-1209

[2]

Banwait S, 2008, J ALZHEIMERS DIS, V13, P1

[3] Neurodegeneration in Alzheimer's disease: caspases and synaptic element interdependence [J].

Bredesen, Dale E. .

MOLECULAR NEURODEGENERATION, 2009, 4

[4] Apoptosis and dependence receptors: A molecular basis for cellular addiction [J].

Bredesen, DE ;

Mehlen, P ;

Rabizadeh, S .

PHYSIOLOGICAL REVIEWS, 2004, 84 (02) :411-430

[5]

Canu N, 1998, J NEUROSCI, V18, P7061

[6]

Christensen Daniel D, 2007, Prim Care Companion J Clin Psychiatry, V9, P32

[7] Caspase activation precedes and leads to tangles [J].

de Calignon, Alix ;

Fox, Leora M. ;

Pitstick, Rose ;

Carlson, George A. ;

Bacskai, Brian J. ;

Spires-Jones, Tara L. ;

Hyman, Bradley T. .

NATURE, 2010, 464 (7292) :1201-U123

[8] Cleavage of atrophin-1 at caspase site aspartic acid 109 modulates cytotoxicity [J].

Ellerby, LM ;

Andrusiak, RL ;

Wellington, CL ;

Hackam, AS ;

Propp, SS ;

Wood, JD ;

Sharp, AH ;

Margolis, RL ;

Ross, CA ;

Salvesen, GS ;

Hayden, MR ;

Bredesen, DE .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (13) :8730-8736

[9] Selective Vulnerability in Alzheimer's Disease: Amyloid Precursor Protein and p75NTR Interaction [J].

Fombonne, Joanna ;

Rabizadeh, Shahrooz ;

Banwait, Surita ;

Mehlen, Patrick ;

Bredesen, Dale E. .

ANNALS OF NEUROLOGY, 2009, 65 (03) :294-303

[10] NEUROIMAGING OUTCOMES IN CLINICAL TRIALS IN ALZHEIMER'S DISEASE [J].

Frisoni, G. B. ;

Delacourte, A. .

JOURNAL OF NUTRITION HEALTH & AGING, 2009, 13 (03) :209-212

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