A sheer pharmacologic approach to compare the contractile effects of PGF2α, DL-cloprostenol and D-cloprostenol on isolated uterine, tracheal, ileal and arterial smooth muscle preparations

被引：8

作者：

Beretta, C ^{[1
]}

Cavalli, M ^{[1
]}

机构：

[1] Univ Milan, Dept Vet Clin Sci, I-20133 Milan, Italy

来源：

THERIOGENOLOGY | 2004年 / 62卷 / 05期

关键词：

PGF(2 alpha); cloprostenol analogs; smooth muscle effects;

D O I：

10.1016/j.theriogenology.2003.12.012

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The contractile effects of PGF(2 alpha), and its cloprostenol analogs (D-enantiomer and racemate) were examined on isolated smooth muscle preparations (uterine, tracheal, ileal and arterial) from rat, guinea-pig and horse. DL- and D-cloprostenol were potent contractors of myometrium, but had negligible secondary effects on other types of smooth muscle, except artery whose response to the D-enantiomer may give rise to some concern. (c) 2004 Elsevier Inc. All rights reserved.

引用

收藏

页码：837 / 846

页数：10

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