Predictive factors of non-treatment and non-persistence to osteoporosis medication after fragility hip fractures at 3 years after discharge: a multicentre, prospective cohort study in the northern Kyushu district of Japan

被引：3

作者：

Kanahori, Masaya ^{[1
]}

Matsumoto, Yoshihiro ^{[1
]}

Fujiwara, Toshifumi ^{[1
]}

Kimura, Atsushi ^{[1
]}

Tsutsui, Tomoko ^{[1
]}

Arisumi, Shinkichi ^{[1
]}

Oyamada, Akiko ^{[2
]}

Ohishi, Masanobu ^{[3
]}

Ikuta, Ko ^{[4
]}

Tsuchiya, Kuniyoshi ^{[5
]}

Tayama, Naohisa ^{[6
]}

Tomari, Shinji ^{[7
]}

Miyahara, Hisaaki ^{[8
]}

Mae, Takao ^{[9
]}

Hara, Toshihiko ^{[10
]}

Saito, Taichi ^{[11
]}

Arizono, Takeshi ^{[12
]}

Kaji, Kozo ^{[13
]}

Mawatari, Taro ^{[14
]}

Fujiwara, Masami ^{[15
]}

Takasaki, Minoru ^{[16
]}

Shin, Kunichika ^{[17
]}

Ninomiya, Kenichi ^{[18
]}

Nakaie, Kazutoshi ^{[19
]}

Antoku, Yasuaki ^{[20
]}

Iwamoto, Yukihide ^{[13
]}

Nakashima, Yasuharu ^{[1
]}

机构：

[1] Kyushu Univ, Grad Sch Med Sci, Dept Orthopaed Surg, Fukuoka, Japan

[2] Saga Handicapped Childrens Hosp, Dept Orthopaed Surg, Saga, Japan

[3] Chihaya Hosp, Dept Orthopaed Surg, Fukuoka, Japan

[4] Karatsu Red Cross Hosp, Dept Orthopaed Surg, Saga, Japan

[5] Japan Community Healthcare Org, Dept Orthopaed Surg, Kyushu Hosp, Fukuoka, Japan

[6] Steel Mem Yawata Hosp, Dept Orthopaed Surg, Fukuoka, Japan

[7] Japanese Red Cross Fukuoka Hosp, Dept Orthopaed Surg, Fukuoka, Japan

[8] Natl Hosp Org Kyushu Med Ctr, Dept Orthopaed Surg, Fukuoka, Japan

[9] Saga Ken Med Ctr Koseikan, Dept Orthopaed Surg, Saga, Japan

[10] Aso Iizuka Hosp, Dept Orthopaed Surg, Fukuoka, Japan

[11] Fukuoka City Hosp, Dept Orthopaed Surg, Fukuoka, Japan

[12] Mutual Aid Assoc Publ Sch Teachers, Dept Orthopaed Surg, Kyushu Cent Hosp, Fukuoka, Japan

[13] Kyushu Rosai Hosp, Dept Orthopaed Surg, Fukuoka, Japan

[14] Hamanomachi Hosp, Dept Orthopaed Surg, Fukuoka, Japan

[15] Sada Hosp, Dept Orthopaed Surg, Fukuoka, Japan

[16] Harasanshin Hosp, Dept Orthopaed Surg, Fukuoka, Japan

[17] Saiseikai Yahata Gen Hosp, Dept Orthopaed Surg, Fukuoka, Japan

[18] Koga Hosp 21, Dept Orthopaed Surg, Fukuoka, Japan

[19] Natl Hosp Org Fukuoka Higashi Med Ctr, Dept Orthopaed Surg, Fukuoka, Japan

[20] Oita Univ, Hosp Informat Ctr, Fac Med, Oita, Japan

来源：

ARCHIVES OF OSTEOPOROSIS | 2021年 / 16卷 / 01期

关键词：

Barthel index; Fragility hip fractures; Osteoporosis; Osteoporosis medication; WOMEN; MEN;

D O I：

10.1007/s11657-021-00988-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We examined osteoporosis medication use and factors affecting persistence in 497 patients with fragility hip fractures. Only 25.5% of patients received continuous medication for 3 years, and 44.1% of patients received no treatment. Low Barthel index at discharge was a risk factor for both non-treatment and non-persistence to osteoporosis medication. Purpose Fragility hip fractures (FHF) caused by osteoporosis decrease the quality of life and worsen life expectancy. Use of osteoporosis medication may be an efficient method in the prevention of secondary FHF. However, previous studies have reported low rates of osteoporosis medication and persistence after FHF. This study aimed to evaluate osteoporosis medication use and factors affecting persistence in patients with FHF in the northern Kyushu area of Japan. Methods A total of 497 FHF patients aged >= 60 years with a 3-year follow-up were included. We prospectively collected data from questionnaires sent every 6 months regarding compliance with osteoporosis medication. We compared baseline characteristics among three groups: no treatment (NT), no persistence (NP), and persistence (P), and conducted multivariable regression models to determine covariates associated with non-treatment (NT vs. NP/P) and non-persistence (NP vs. P). Results There were 219 (44.1%), 151 (30.4%), and 127 (25.5%) patients in the NT, NP, and P groups, respectively. Factors associated with non-treatment were male sex, chronic kidney disease, no previous osteoporosis treatment, and low Barthel index (BI) at discharge. The only factor associated with non-persistence was a low BI at discharge. Factors associated with a low BI at discharge were male sex, older age, trochanteric fracture, and surgical delay. Conclusion Low BI at discharge is a risk factor for both non-treatment and non-persistence to osteoporosis medication. Therefore, appropriate interventions to improve BI may result in persistence to osteoporosis medication.

引用

页数：12

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