The Link Between Ferroptosis and Cardiovascular Diseases: A Novel Target for Treatment

被引：71
作者：
Hu, Huilin [1 ]
Chen, Yunqing [2 ]
Jing, Lele [1 ]
Zhai, Changlin [1 ]
Shen, Liang [1 ]
机构：
[1] Jiaxing Univ, Dept Cardiol, Affiliated Hosp, Jiaxing, Zhejiang, Peoples R China
[2] Jiaxing Univ, Dept Infect, Affiliated Hosp, Jiaxing, Zhejiang, Peoples R China
来源：
FRONTIERS IN CARDIOVASCULAR MEDICINE | 2021年 / 8卷
关键词：
cardiovascular diseases; ferroptosis; iron; therapeutic target; lipid peroxidation; ERASTIN-INDUCED FERROPTOSIS; CELL-DEATH; DIABETIC CARDIOMYOPATHY; LIPID-PEROXIDATION; OXIDATIVE STRESS; CANCER-CELLS; IRON; INHIBITION; METABOLISM; AUTOPHAGY;
D O I：
10.3389/fcvm.2021.710963
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Ferroptosis is an iron-dependent cell death, which is characterized by iron overload and lipid peroxidation. Ferroptosis is distinct from apoptosis, necroptosis, autophagy, and other types of cell death in morphology and function. Ferroptosis is regulated by a variety of factors and controlled by several mechanisms, including mitochondria! activity and metabolism of iron, lipid, and amino acids. Accumulating evidence shows that ferroptosis is closely related to a majority of cardiovascular diseases (CVDs), including cardiomyopathy, myocardial infarction, ischemia/reperfusion injury, heart failure, and atherosclerosis. This review summarizes the current status of ferroptosis and discusses ferroptosis as a potential therapeutic target for CVDs.
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页数：12
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