In vitro crosstalk between fibroblasts and native human acute myelogenous leukemia (AML) blasts via local cytokine networks results in increased proliferation and decreased apoptosis of AML cells as well as increased levels of proangiogenic Interleukin 8

被引：59

作者：

Ryningen, A ^{[1
]}

Wergeland, L

Glenjen, N

Gjertsen, BT

Bruserud, O

机构：

[1] Haukeland Hosp, Dept Med, Div Hematol, N-5021 Bergen, Norway

[2] Univ Bergen, N-5021 Bergen, Norway

来源：

LEUKEMIA RESEARCH | 2005年 / 29卷 / 02期

关键词：

acute myelogenous leukemia; fibroblasts; proliferation; apoptosis; Interleukin; 8;

D O I：

10.1016/j.leukres.2004.06.008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Interactions between native human acute myelogenous leukemia (AML) blasts and nonleukemic cells in the bone marrow microenvironment seem important both for disease development chemosensitivity. Native human AML blasts from consecutive patients were cultured with normal human bone marrow stromal cells and two fibroblast lines (HFL1 and Hs27) separated by a semipermeable membrane. This bidirectional crosstalk via the cytokine network between AML blasts and fibroblasts caused (i) increased proliferation, (ii) mediated antiapoptotic signalling and (iii) increased local levels of proangiogenic IL8. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：185 / 196

页数：12

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