Synthesis of a 11C-labelled derivative of the N-methyl-D-aspartate receptor antagonist MK-801

被引：0

作者：

Andersson, Y

Tyrefors, N

Sihver, S

Onoe, H

Watanabe, Y

Tsukada, H

Langstrom, B ^{[1
]}

机构：

[1] Univ Uppsala, PET Ctr, UAS, S-75185 Uppsala, Sweden

[2] JST, Subfemtomole Biorecognit Project, Uppsala, Sweden

[3] Osaka Biosci Inst, Dept Neurosci, Osaka, Japan

[4] Hamamatsu Photon, Cent Res Lab, Hamakita, Japan

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1998年 / 41卷 / 06期

关键词：

NMDA-receptor; MK-801; palladium-promoted C-11-cyanation; C-11]cyano-MK-801; positron emission tomography; in vivo investigation;

D O I：

10.1002/(SICI)1099-1344(199806)41:6<567::AID-JLCR96>3.0.CO;2-8

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A one-pot synthesis of (+)-3-[C-11]cyano-MK-801 was performed using a palladium-promoted reaction of hydrogen [C-11]cyanide with (+)-3-iodo-MK-801. The synthesis time was 32 min counted from end of bombardment, affording (+)-3-[C-11]cyano-MK-801 in 37 % decay-corrected radiochemical yield based on hydrogen [C-11]cyanide. The radiochemical purity was higher than 95 % and the specific radioactivity was in the range of 220-600 GBq/mu mol. In vitro investigations in homogenate and frozen sections of rat brain indicated that (+)-3-[C-11]cyano-MK-801 may be used as tracer in studies of the NMDA receptor.

引用

页码：567 / 576

页数：10

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