Synthesis of 2-deoxy-2-fluoro-phosphatidylinositol-4,5-bisphosphate and analogues: Probes and modulators of the mammalian PI-PLCs

被引：2
作者：
Aneja, SG [1 ]
Ivanova, PT [1 ]
Aneja, R [1 ]
机构：
[1] Cornell Univ, Langmuir Lab, Funct Lipids Div, Nutrimed Biotech, Ithaca, NY 14850 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 09期
关键词：
D O I：
10.1016/S0960-894X(98)00172-3
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
An approach to synthesis of 2-modified phosphatidylinositol-4,5-bisphosphates, which are substrate analogues useful as probes and modulators of the PI-PLC enzyme family, is described and illustrated for the dibutyl-2-deoxy-2-fluoro analogue, a probe designed for delineating substrate and PI-PLC interactions by X-ray crystallography. (C) 1998 Elsevier Science Ltd. All rights reserved.
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页码：1061 / 1064
页数：4
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