共 124 条
Cellular pathogenesis in prion diseases
被引:20
作者:

Crozet, Carole
论文数: 0 引用数: 0
h-index: 0
机构:
CNRS, Inst Genet Humaine, UPR1142, F-34396 Montpellier 5, France CNRS, Inst Genet Humaine, UPR1142, F-34396 Montpellier 5, France

Beranger, Florence
论文数: 0 引用数: 0
h-index: 0
机构:
CNRS, Inst Genet Humaine, UPR1142, F-34396 Montpellier 5, France CNRS, Inst Genet Humaine, UPR1142, F-34396 Montpellier 5, France

Lehmann, Sylvain
论文数: 0 引用数: 0
h-index: 0
机构:
CNRS, Inst Genet Humaine, UPR1142, F-34396 Montpellier 5, France CNRS, Inst Genet Humaine, UPR1142, F-34396 Montpellier 5, France
机构:
[1] CNRS, Inst Genet Humaine, UPR1142, F-34396 Montpellier 5, France
关键词:
prion;
neurodegeneration;
cell death;
neuronal dysfunction;
gliosis;
D O I:
10.1051/vetres:2008021
中图分类号:
S85 [动物医学(兽医学)];
学科分类号:
0906 ;
摘要:
Prion diseases are characterised by neuronal loss, vacuolation (spongiosis), reactive astrocytosis, microgliosis and in most cases by the accumulation in the central nervous system of the abnormal prion protein, named PrPSc. In this review on the "cellular pathogenesis in prion diseases", we have chosen to highlight the main mechanisms underlying the impact of PrPC/PrPSc on neurons: the neuronal dysfunction, the neuronal cell death and its relation with PrPSc accumulation, as well as the role of PrPSc in the microglial and astrocytic reaction.
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页数:17
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共 124 条
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CNRS, Inst Genet Humaine, UPR 1142, F-34396 Montpellier 5, France CNRS, Inst Genet Humaine, UPR 1142, F-34396 Montpellier 5, France

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机构: Netherlands Canc Inst, Antoni Van Leeuwenhoek Hosp, NL-1066 CX Amsterdam, Netherlands

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机构: Netherlands Canc Inst, Antoni Van Leeuwenhoek Hosp, NL-1066 CX Amsterdam, Netherlands

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机构: Netherlands Canc Inst, Antoni Van Leeuwenhoek Hosp, NL-1066 CX Amsterdam, Netherlands