Effects of Dicaffeoylquinic Acids from Ilex kudingcha on Lipid Metabolism and Intestinal Microbiota in High-Fat-Diet-Fed Mice

被引：40

作者：

Xie, Minhao ^{[1
,2
]}

Chen, Guijie ^{[2
]}

Wan, Peng ^{[2
]}

Dai, Zhuqing ^{[2
]}

Zeng, Xiaoxiong ^{[2
]}

Sun, Yi ^{[2
]}

机构：

[1] Nanjing Univ Finance & Econ, Collaborat Innovat Ctr Modern Grain Circulat & Sa, Coll Food Sci & Engn, Nanjing 210023, Jiangsu, Peoples R China

[2] Nanjing Agr Univ, Coll Food Sci & Technol, Nanjing 210095, Jiangsu, Peoples R China

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2019年 / 67卷 / 01期

基金：

中国国家自然科学基金;

关键词：

kudingcha; dicaffeoylquinic acids; lipid metabolism; inflammation; intestinal microbiota; GUT MICROBIOTA; AKKERMANSIA-MUCINIPHILA; OBESITY; POLYPHENOLS; TEA; CHOLESTEROL; BIFIDOBACTERIA; MODULATION; INCREASES; EFFICACY;

D O I：

10.1021/acs.jafc.8b05444

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

Kudingcha made from the leaves of Ilex kudingcha and chlorogenic acid have antiobesity and intestinal microbiota modulating effects. However, the effects of kudingcha dicaffeoylquinic acids (diCQAs) on obesity and intestinal microbiota are still poorly understood. In the present study, the effects of kudingcha diCQAs on adipose accumulation and intestinal microbiota were investigated in high-fat-diet-fed mice. As a result, kudingcha diCQAs decreased the liver and adipose tissue masses, concentrations of serum inflammatory factors, and hepatic expressions of lipid synthesis related genes and increased the expressions of genes involved in lipid degradation in the liver. Kudingcha diCQAs also exhibited considerable effects on intestinal microbiota. They increased the relative abundances of Bifidobacterium and Akkermansia and affected the function of the microbial community including bile acid biosynthesis. Kudingcha diCQAs had antiobesity potential, possibly acting through affecting intestinal microbiota. Furthermore, the effects of kudingcha diCQAs on fat accumulation and intestinal microbiota had a dose-dependent manner.

引用

页码：171 / 183

页数：13

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