Harnessing IL-15 signaling to potentiate NK cell-mediated cancer immunotherapy

被引：106

作者：

Ma, Shoubao ^{[1
,2
]}

Caligiuri, Michael A. ^{[1
,2
,3
]}

Yu, Jianhua ^{[1
,2
,3
,4
]}

机构：

[1] City Hope Natl Med Ctr, Dept Hematol & Hematopoiet Cell Transplantat, Los Angeles, CA 91010 USA

[2] City Hope Natl Med Ctr, Hematol Malignancies & Stem Cell Transplantat Inst, Los Angeles, CA 91010 USA

[3] City Hope Natl Med Ctr, Comprehens Canc Ctr, Los Angeles, CA 91010 USA

[4] City Hope Natl Med Ctr, Beckman Res Inst, Dept Immuno Oncol, Los Angeles, CA 91010 USA

来源：

TRENDS IN IMMUNOLOGY | 2022年 / 43卷 / 10期

基金：

美国国家卫生研究院;

关键词：

NATURAL-KILLER-CELLS; RECOMBINANT HUMAN INTERLEUKIN-15; CD8; T-CELLS; RECEPTOR-ALPHA; CBL-B; SOLUBLE IL-15R-ALPHA; NEGATIVE REGULATOR; TUMOR PROGRESSION; DENDRITIC CELLS; CLINICAL-TRIAL;

D O I：

10.1016/j.it.2022.08.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Natural killer (NK) cells, a crucial component of the innate immune system, have long been of clinical interest for their antitumor properties. Almost every aspect of NK cell immunity is regulated by interleukin-15 (IL-15), a cytokine in the common gamma-chain family. Several current clinical trials are using IL-15 or its ana-logs to treat various cancers. Moreover, NK cells are being genetically modified to produce membrane-bound or secretory IL-15. Here, we discuss the key role of IL-15 signaling in NK cell immunity and provide an up-to-date overview of IL-15 in NK cell therapy.

引用

页码：833 / 847

页数：15

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