Label-free colorimetric detection of lead ions with a nanomolar detection limit and tunable dynamic range by using gold nanoparticles and DNAzyme

被引:392
作者
Wang, Zidong [1 ]
Lee, Jung Heon [1 ]
Lu, Yi [1 ,2 ]
机构
[1] Univ Illinois, Dept Mat Sci & Engn, Beckman Inst Adv Sci & Technol, Urbana, IL 61801 USA
[2] Univ Illinois, Dept Chem, Urbana, IL 61801 USA
关键词
D O I
10.1002/adma.200703181
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
In the presence of Pb2+, a cleaved enzyme-substrate complex releases ssDNA that adsorbs onto and stabilizes gold nanoparticles (AuNPs) against salt-induced aggregation. In the absence of Pb2+, the uncleaved complex can not stabilize the AuNPs, resulting in purple-blue AuNP aggregates (see figure). The sensor has a low detection limit of 3 nM, a high selectivity, and a tunable dynamic range.
引用
收藏
页码:3263 / +
页数:6
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